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Low-density lipoprotein cholesterol to apolipoprotein B ratio predicts mortality and cardiovascular events in peritoneal dialysis patients.
Zeng, Chuanfei; Zhan, Qing; Lv, Linghai; Chen, Yanbing; Zhan, Xiaojiang.
Afiliación
  • Zeng C; Department of Nephrology, The First Affiliated Hospital of Nanchang University, 17#Yongwai Street, Nanchang, 330006, Jiangxi, China.
  • Zhan Q; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Lv L; Department of Nephrology, The First Affiliated Hospital of Nanchang University, 17#Yongwai Street, Nanchang, 330006, Jiangxi, China.
  • Chen Y; Fuzhou Medical College, Nanchang University, Fuzhou, 344000, Jiangxi, China.
  • Zhan X; Department of Nephrology, The First Affiliated Hospital of Nanchang University, 17#Yongwai Street, Nanchang, 330006, Jiangxi, China.
Int Urol Nephrol ; 55(8): 2015-2023, 2023 Aug.
Article en En | MEDLINE | ID: mdl-36808396
PURPOSE: The ratio of low-density lipoprotein cholesterol (LDL-C)/apolipoprotein B (apo B) is associated with all-cause mortality and cardiovascular events in chronic kidney disease patients. The aim of this study was to investigate the association between the LDL-C/apo B ratio (LAR) and all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. METHODS: A total of 1199 incident PD patients were enrolled from November 1, 2005 to August 31, 2019. The LAR was used to divide the patients into two groups by X-Tile software and restricted cubic splines using 1.04 as the cutoff. The incidence of all-cause mortality and cardiovascular events at follow-up was compared according to LAR. RESULTS: Of the 1199 patients, 58.0% were men, the mean age was 49.3 ± 14.5 years, 225 patients had a history of diabetes, and 117 patients had prior cardiovascular disease. During the follow-up period, 326 patients died, and 178 patients experienced cardiovascular events. After full adjustment, a low LAR was significantly associated with HRs for all-cause mortality of 1.37 (95% CI 1.02-1.84, P = 0.034) and for cardiovascular events of 1.61 (95% CI 1.10-2.36, P = 0.014). CONCLUSION: This study suggests that a low LAR is an independent risk factor for all-cause mortality and cardiovascular events in PD patients, indicating that the LAR may provide significant information when assessing all-cause mortality and cardiovascular risks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diálisis Peritoneal Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int Urol Nephrol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diálisis Peritoneal Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int Urol Nephrol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos