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'Potentially curative therapies' for hepatocellular carcinoma: how many patients can actually be cured?
Cucchetti, Alessandro; Elshaarawy, Omar; Han, Guohong; Chong, Charing C N; Serra, Carla; O'Rourke, Joanne Marie; Crew, Richard; Felicani, Cristina; Ercolani, Giorgio; Shah, Tahir; Vogel, Arndt; Lai, Paul B S; Johnson, Philip J.
Afiliación
  • Cucchetti A; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
  • Elshaarawy O; Morgagni-Pierantoni Hospital, Forlì, Italy.
  • Han G; National Liver Institute, Shebeen El-Kom, Egypt.
  • Chong CCN; Department of Liver Disease and Digestive Interventional Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Serra C; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong SAR.
  • O'Rourke JM; IRCCS Azienda Ospedaliero-Universitaria di Bologna. S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Crew R; The Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Felicani C; Technology, Infrastructure & Environment Directorate, Faculty of Health & Life Sciences, University of Liverpool, Liverpool, UK.
  • Ercolani G; IRCCS Azienda Ospedaliero-Universitaria di Bologna. S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
  • Shah T; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
  • Vogel A; Morgagni-Pierantoni Hospital, Forlì, Italy.
  • Lai PBS; The Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Johnson PJ; Clinic for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Br J Cancer ; 128(9): 1665-1671, 2023 05.
Article en En | MEDLINE | ID: mdl-36807338
BACKGROUND: Treatment of hepatocellular carcinoma (HCC) is predicated on early diagnosis such that 'curative therapies' can be successfully applied. The term 'curative' is, however, poorly quantitated. We aimed to complement our previous work by developing a statistical model to predict cure after ablation and to use this analysis to compare the true curative potential of the various 'curative' therapies. METHODS: We accessed data from 1571 HCC patients treated in 5 centres receiving radiofrequency (RFA) or microwave (MWA) ablation and used flexible parametric modelling to determine the curative fraction. The results of this analysis were then combined with our previous estimations to provide a simple calculator applicable to all patients undergoing potentially curative therapies. RESULTS: The cure fraction was 18.3% rising to about 40% in patients with good liver function and very small tumours. CONCLUSION: Cure for HCC treated with ablation occurs in the order of 20% to 30%, similar to that achievable by resection but much inferior to transplantation where the analogous figure is >70%. We provide a 'calculator' that permits clinicians to estimate the chance of cure for any individual patient, based on readily available clinical features.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Terapia por Radiofrecuencia / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Terapia por Radiofrecuencia / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido