Design and discovery of novel dipeptide boronic acid ester proteasome inhibitors, an oral slowly-released prodrug for the treatment of multiple myeloma.

Wang, Xueyuan; Zhang, Wen; Wen, Tiantian; Miao, Hang; Hu, Wenjiao; Liu, Hailong; Lei, Meng; Zhu, Yongqiang

Wang, Xueyuan; Zhang, Wen; Wen, Tiantian; Miao, Hang; Hu, Wenjiao; Liu, Hailong; Lei, Meng; Zhu, Yongqiang.

Afiliación

Wang X; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China.
Zhang W; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China.
Wen T; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China.
Miao H; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China.
Hu W; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China.
Liu H; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China.
Lei M; College of Science, Nanjing Forestry University, No. 159 Longpan Road, Nanjing, 210037, PR China; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing, 210046, PR China. Electronic address: hk-lm@163.com.
Zhu Y; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210037, PR China; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing, 210046, PR China. Electronic address: zhyqscu@hotmail.com.

Eur J Med Chem ; 250: 115187, 2023 Mar 15.

Article en En | MEDLINE | ID: mdl-36806958

Asunto(s)

Antineoplásicos; Mieloma Múltiple; Profármacos; Humanos; Ratones; Animales; Inhibidores de Proteasoma/farmacología; Inhibidores de Proteasoma/química; Ácidos Borónicos/química; Mieloma Múltiple/tratamiento farmacológico; Mieloma Múltiple/patología; Profármacos/farmacología; Profármacos/uso terapéutico; Dipéptidos/farmacología; Dipéptidos/química; Complejo de la Endopetidasa Proteasomal/metabolismo; Citratos/uso terapéutico; Antineoplásicos/química; Línea Celular Tumoral

Palabras clave

In vivo antitumor activity; Multiple myeloma; Pharmacokinetic; Prodrug; Proteasome; Structure-activity relationships

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Mieloma Múltiple / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article Pais de publicación: Francia

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