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Lipophorin receptor is required for the accumulations of cuticular hydrocarbons and ovarian neutral lipids in Locusta migratoria.
Zhao, Yiyan; Liu, Weimin; Zhao, Xiaoming; Yu, Zhitao; Guo, Hongfang; Yang, Yang; Moussian, Bernard; Zhu, Kun Yan; Zhang, Jianzhen.
Afiliación
  • Zhao Y; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China; College of Life Science, Shanxi University, Taiyuan, China.
  • Liu W; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address: liuweimin@sxu.edu.cn.
  • Zhao X; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China.
  • Yu Z; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China.
  • Guo H; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China; College of Life Science, Shanxi University, Taiyuan, China.
  • Yang Y; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China; College of Life Science, Shanxi University, Taiyuan, China.
  • Moussian B; Interfaculty Institute of Cell Biology, University of Tübingen, 72076 Tübingen, Germany; Université Côte d'Azur, INRAE, CNRS, Institut Sophia Agrobiotech, 06903 Sophia Antipolis CEDEX, France.
  • Zhu KY; Department of Entomology, 123 Waters Hall, Kansas State University, Manhattan, KS 66506, USA.
  • Zhang J; Research Institute of Applied Biology, Shanxi Key Laboratory of Nucleic Acid Biopesticides, The Key Laboratory of Chemical Biology and Molecular, Engineering of Ministry of Education, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address: zjz@sxu.edu.cn.
Int J Biol Macromol ; 236: 123746, 2023 May 01.
Article en En | MEDLINE | ID: mdl-36806776
Lipophorin is the most abundant lipoprotein particle in insect hemolymph. Lipophorin receptor (LPR) is a glycoprotein that binds to the lipophorin and mediates cellular uptake and metabolism of lipids by endocytosis. However, the roles of LPR in uptake of lipids in the integument and ovary remain unknown in the migratory locust (Locusta migratoria). In present study, we characterized the molecular properties and biological roles of LmLPR in L. migratoria. The LmLPR transcript level was high in the first 2 days of the adults after eclosion, then gradually declined. LmLPR was predominately expressed in fat body, ovary and integument. Using immuno-detection methods, we revealed that LmLPR was mainly localized in the membrane of oenocytes, epidermal cells, fat body cells and follicular cells. RNAi-mediated silencing of LmLPR led to a slight decrease of the cuticle hydrocarbon contents but with little effect on the cuticular permeability. However, the neutral lipid content was significantly decreased in the ovary after RNAi against LmLPR, which led to a retarded ovarian development. Taken together, our results indicated that LmLPR is involved in the uptake and accumulation of lipids in the ovary and plays a crucial role in ovarian development in L. migratoria. Therefore, LmLPR could be a promising RNAi target for insect pest management by disrupting insect ovarian development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Locusta migratoria Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Locusta migratoria Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos