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Preoperative neutrophil-to-lymphocyte ratio is prognostic for early recurrence after curative intrahepatic cholangiocarcinoma resection.
Choi, Woo Jin; Perez, Fiorella Murillo; Gravely, Annabel; Ivanics, Tommy; Claasen, Marco P A W; Abraham, Liza; Abreu, Phillipe; Visser, Robin; Gallinger, Steven; Hansen, Bettina E; Sapisochin, Gonzalo.
Afiliación
  • Choi WJ; Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Perez FM; HPB Surgical Oncology, University Health Network, Toronto, ON, Canada.
  • Gravely A; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
  • Ivanics T; Toronto Center for Liver Disease, University Health Network, Toronto, ON, Canada.
  • Claasen MPAW; Toronto Center for Liver Disease, University Health Network, Toronto, ON, Canada.
  • Abraham L; HPB Surgical Oncology, University Health Network, Toronto, ON, Canada.
  • Abreu P; Department of Surgery, Henry Ford Hospital, Detroit, MI, United States.
  • Visser R; Department of Surgical Sciences, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden.
  • Gallinger S; HPB Surgical Oncology, University Health Network, Toronto, ON, Canada.
  • Hansen BE; Division of HPB & Transplant Surgery, Department of Surgery, Erasmus MC Transplant Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
  • Sapisochin G; Department of Surgery, University of Toronto, Toronto, ON, Canada.
Ann Hepatobiliary Pancreat Surg ; 27(2): 158-165, 2023 May 31.
Article en En | MEDLINE | ID: mdl-36804209
Backgrounds/Aims: Within two years of surgery, 70% of resected intrahepatic cholangiocarcinoma (iCCA) recur. Better biomarkers are needed to identify those at risk of "early recurrence" (ER). In this study, we defined ER and investigated whether preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-inflammatory index were prognostic of both overall relapse and ER after curative hepatectomy for iCCA. Methods: A retrospective cohort of patients who underwent curative-intent hepatectomy for iCCA between 2005 and 2017 were created. The cut-off timepoint for the ER of iCCA was estimated using a piecewise linear regression model. Univariable analyses of recurrence were conducted for the overall, early, and late recurrence periods. For the early and late recurrence periods, multivariable Cox regression with time-varying regression coefficient analysis was used. Results: A total of 113 patients were included in this study. ER was defined as recurrence within 12 months of a curative resection. Among the included patients, 38.1% experienced ER. In the univariable model, a higher preoperative NLR (> 4.3) was significantly associated with an increased risk of recurrence overall and in the first 12 months after curative surgery. In the multivariable model, a higher NLR was associated with a higher recurrence rate overall and in the ER period (≤ 12 months), but not in the late recurrence period. Conclusions: Preoperative NLR was prognostic of both overall recurrence and ER after curative iCCA resection. NLR is easily obtained before and after surgery and should be integrated into ER prediction tools to guide preoperative treatments and intensify postoperative follow-up.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ann Hepatobiliary Pancreat Surg Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ann Hepatobiliary Pancreat Surg Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Corea del Sur