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Discovery of a rapidly evolving yeast defense factor, KTD1, against the secreted killer toxin K28.
Andreev, Ilya; Laidlaw, Kamilla M E; Giovanetti, Simone M; Urtecho, Guillaume; Shriner, Daniel; Bloom, Joshua S; MacDonald, Chris; Sadhu, Meru J.
Afiliación
  • Andreev I; Computational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
  • Laidlaw KME; Biology Department, University of York, York YO10 5DD, UK.
  • Giovanetti SM; York Biomedical Research Institute, University of York, York YO10 5NG, UK.
  • Urtecho G; Computational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
  • Shriner D; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA 90095.
  • Bloom JS; Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
  • MacDonald C; Department of Human Genetics, University of California, Los Angeles, CA 90095.
  • Sadhu MJ; Department of Biological Chemistry, University of California, Los Angeles, CA 90095.
Proc Natl Acad Sci U S A ; 120(8): e2217194120, 2023 02 21.
Article en En | MEDLINE | ID: mdl-36800387
Secreted protein toxins are widely used weapons in conflicts between organisms. Elucidating how organisms genetically adapt to defend themselves against these toxins is fundamental to understanding the coevolutionary dynamics of competing organisms. Within yeast communities, "killer" toxins are secreted to kill nearby sensitive yeast, providing a fitness advantage in competitive growth environments. Natural yeast isolates vary in their sensitivity to these toxins, but to date, no polymorphic genetic factors contributing to defense have been identified. We investigated the variation in resistance to the killer toxin K28 across diverse natural isolates of the Saccharomyces cerevisiae population. Using large-scale linkage mapping, we discovered a novel defense factor, which we named KTD1. We identified many KTD1 alleles, which provided different levels of K28 resistance. KTD1 is a member of the DUP240 gene family of unknown function, which is rapidly evolving in a region spanning its two encoded transmembrane helices. We found that this domain is critical to KTD1's protective ability. Our findings implicate KTD1 as a key polymorphic factor in the defense against K28 toxin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxinas Biológicas / Proteínas de Saccharomyces cerevisiae / Micotoxinas Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxinas Biológicas / Proteínas de Saccharomyces cerevisiae / Micotoxinas Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos