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High prevalence of potential psychotropic drugs interactions among Brazilian dental patients.
Cruz, Alex Junio Silva; Martins, Maria Auxiliadora Parreiras; de Aguilar, Diego Rodrigues; Santos, Jacqueline Silva; Sohn, Woosung; de Castilho, Lia Silva; Abreu, Mauro Henrique Nogueira Guimarães.
Afiliación
  • Cruz AJS; Graduate Program, School of Dentistry, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, Brazil.
  • Martins MAP; Department of Pharmaceutical Products, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, Brazil.
  • de Aguilar DR; Graduate Program, School of Dentistry, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, Brazil.
  • Santos JS; Graduate Program, School of Dentistry, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, Brazil.
  • Sohn W; Department of Population Oral Health, School of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
  • de Castilho LS; Department of Operative Dentistry, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, Brazil.
  • Abreu MHNG; Department of Community and Preventive Dentistry, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, Brazil.
Oral Dis ; 2023 Feb 16.
Article en En | MEDLINE | ID: mdl-36794905
OBJECTIVE: To determine the prevalence of potential drug-drug interactions involving psychotropics prescribed by dentists, and dispensed by the public healthcare system, as well as to describe the severity and level of evidence of those interactions in the state of Minas Gerais, Brazil. MATERIALS AND METHODS: We conducted data analysis from pharmaceutical claims in which dental patients received systemic psychotropics in 2017. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The outcome was the occurrence of potential drug-drug interactions, which were detected according to IBM Micromedex®. Independent variables were the patient's sex, age, and the number of drugs used. Descriptive statistics was performed using SPSS v. 26. RESULTS: Overall, 1480 individuals were prescribed psychotropic drugs. The prevalence of potential drug-drug interactions was 24.8% (n = 366). The total of 648 interactions was observed and, most of which were of major severity (n = 438, 67.6%). Most interactions occurred in female individuals (n = 235; 64.2%), with 46.0 (±17.3) years-old, concurrently taking 3.7 (±1.9) drugs. CONCLUSION: A substantial proportion of dental patients presented potential drug-drug interactions, mostly of major severity, which might be life-threatening.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prevalence_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Oral Dis Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prevalence_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Oral Dis Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca