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Conjunctival melanoma following cornea transplant from a cancer donor: A case report.
Kwitko, Sergio; Marafon, Samara Barbara; Simao, Mariana Fernandez; Giacomini, Fernanda; Marinho, Diane Ruschel.
Afiliación
  • Kwitko S; Ophthalmology Department of Hospital de Clinicas de Porto Alegre, 2350 Ramiro Barcelos St, Room 17 B1, Porto Alegre, RS, 90035-007, Brazil.
  • Marafon SB; Oftalmocentro, 724 Doutor Nilo Pecanha Avenue, Room 404, Porto Alegre, RS, 90470-000, Brazil.
  • Simao MF; Ophthalmology Department of Hospital de Clinicas de Porto Alegre, 2350 Ramiro Barcelos St, Room 17 B1, Porto Alegre, RS, 90035-007, Brazil.
  • Giacomini F; Oftalmocentro, 724 Doutor Nilo Pecanha Avenue, Room 404, Porto Alegre, RS, 90470-000, Brazil.
  • Marinho DR; Ophthalmology Department of Hospital de Clinicas de Porto Alegre, 2350 Ramiro Barcelos St, Room 17 B1, Porto Alegre, RS, 90035-007, Brazil.
Am J Ophthalmol Case Rep ; 29: 101809, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36793795
Purpose: Conjunctival melanoma is a rare ocular tumor. We report a case of ocular conjunctival melanoma during topical immunosuppression, after a corneal transplant from a donor with metastatic melanoma. Observation: A 59-year-old white male presented with a progressive nonpigmented conjunctival lesion in his right eye. He had previously undergone two penetrating keratoplasties, and he was being treated with topical immunosuppression with 0.03% tacrolimus (Ophthalmos Pharma; Sao Paulo, SP/Brazil). The histopathology evaluation revealed the nodule to be a conjunctival epithelioid melanoma. The donor's death cause was disseminated melanoma. Conclusion and importance: The correlation between cancer and systemic immunosuppression after a solid organ transplant is widely known. The local influence, however, has not been reported. In this case, a causal relationship was not established. The correlation between conjunctival melanoma, exposure to topical tacrolimus immunosuppressive therapy, and the malignance characteristic of donor cornea should be better evaluated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Ophthalmol Case Rep Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Ophthalmol Case Rep Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos