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High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens.
Yuen, Jason; Goyal, Abhinav; Rusheen, Aaron E; Kouzani, Abbas Z; Berk, Michael; Kim, Jee Hyun; Tye, Susannah J; Blaha, Charles D; Bennet, Kevin E; Lee, Kendall H; Shin, Hojin; Oh, Yoonbae.
Afiliación
  • Yuen J; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Goyal A; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Barwon Health, Deakin University, Geelong, VIC, Australia.
  • Rusheen AE; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Kouzani AZ; Medical Scientist Training Program, Mayo Clinic, Rochester, MN, United States.
  • Berk M; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Kim JH; Medical Scientist Training Program, Mayo Clinic, Rochester, MN, United States.
  • Tye SJ; School of Engineering, Deakin University, Geelong, VIC, Australia.
  • Blaha CD; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Barwon Health, Deakin University, Geelong, VIC, Australia.
  • Bennet KE; The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Barwon Health, Deakin University, Geelong, VIC, Australia.
  • Lee KH; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
  • Shin H; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Oh Y; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
Front Neurosci ; 17: 1061578, 2023.
Article en En | MEDLINE | ID: mdl-36793536
Cocaine's addictive properties stem from its capacity to increase tonic extracellular dopamine levels in the nucleus accumbens (NAc). The ventral tegmental area (VTA) is a principal source of NAc dopamine. To investigate how high frequency stimulation (HFS) of the rodent VTA or nucleus accumbens core (NAcc) modulates the acute effects of cocaine administration on NAcc tonic dopamine levels multiple-cyclic square wave voltammetry (M-CSWV) was used. VTA HFS alone decreased NAcc tonic dopamine levels by 42%. NAcc HFS alone resulted in an initial decrease in tonic dopamine levels followed by a return to baseline. VTA or NAcc HFS following cocaine administration prevented the cocaine-induced increase in NAcc tonic dopamine. The present results suggest a possible underlying mechanism of NAc deep brain stimulation (DBS) in the treatment of substance use disorders (SUDs) and the possibility of treating SUD by abolishing dopamine release elicited by cocaine and other drugs of abuse by DBS in VTA, although further studies with chronic addiction models are required to confirm that. Furthermore, we demonstrated the use of M-CSWV can reliably measure tonic dopamine levels in vivo with both drug administration and DBS with minimal artifacts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza