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Upregulation of TUBG1 expression promotes hepatocellular carcinoma development.
Wang, Zi-Jian; Dai, Zhi-Zheng; Hu, Mei-Zhen; Liu, Jun-Nan; Liang, Hang; Shen, Mei-Mei; Zhu, Shu-Juan; Sheng, Hua-Jun; Gao, Jian; Huang, Ai-Long; Tang, Kai-Fu.
Afiliación
  • Wang ZJ; Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Dai ZZ; The First Clinical College, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Hu MZ; Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Liu JN; Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Liang H; School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Shen MM; School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Zhu SJ; Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Sheng HJ; School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Gao J; School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Huang AL; Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • Tang KF; Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Med Oncol ; 40(3): 96, 2023 Feb 15.
Article en En | MEDLINE | ID: mdl-36792863
Tubulin γ-1 (TUBG1) is a highly conserved component of the centrosome and its deregulation is involved in the development of several types of cancer. However, the role of TUBG1 in hepatocellular carcinoma (HCC) remains unclear. In this study, we found that TUBG1 was upregulated in human HCC cells and tissues and that TUBG1 upregulation was associated with promoter hypomethylation in HCC tissues. TUBG1 knockdown suppressed the proliferation, invasion, and migration of HCC cells. While TUBG1 expression was positively correlated with CD4 + memory T lymphocyte infiltration, it was negatively correlated with CD4 + regulatory T-cell infiltration in human HCC tissues. Furthermore, TUBG1 expression was positively correlated with the expression of genes involved in cell division. Noticeably, high expression of TUBG1 was associated with poor prognosis in patients with HCC. Overall, our findings revealed that TUBG1 promotes hepatocarcinogenesis by increasing proliferation, invasion, and migration of HCC cells and may regulate T lymphocyte infiltration. The current findings provide important insights into TUBG1 regulation in HCC, which could provide new therapeutic targets for hepatocarcinoma which has a very high incidence and mortality rate worldwide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos