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The gut microbiome and early-life growth in a population with high prevalence of stunting.
Robertson, Ruairi C; Edens, Thaddeus J; Carr, Lynnea; Mutasa, Kuda; Gough, Ethan K; Evans, Ceri; Geum, Hyun Min; Baharmand, Iman; Gill, Sandeep K; Ntozini, Robert; Smith, Laura E; Chasekwa, Bernard; Majo, Florence D; Tavengwa, Naume V; Mutasa, Batsirai; Francis, Freddy; Tome, Joice; Stoltzfus, Rebecca J; Humphrey, Jean H; Prendergast, Andrew J; Manges, Amee R.
Afiliación
  • Robertson RC; Blizard Institute, Queen Mary University of London, London, UK.
  • Edens TJ; Microenvironment & Immunity Unit, INSERM U1224, Institut Pasteur, 75015, Paris, France.
  • Carr L; Devil's Staircase Consulting, West Vancouver, BC, Canada.
  • Mutasa K; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
  • Gough EK; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Evans C; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Geum HM; Blizard Institute, Queen Mary University of London, London, UK.
  • Baharmand I; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Gill SK; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
  • Ntozini R; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
  • Smith LE; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
  • Chasekwa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Majo FD; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Tavengwa NV; Department of Public and Ecosystem Health, Cornell University, Ithaca, NY, USA.
  • Mutasa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Francis F; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Tome J; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Stoltzfus RJ; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Humphrey JH; Department of Experimental Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Prendergast AJ; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
  • Manges AR; Goshen College, Goshen, Indiana, IN, USA.
Nat Commun ; 14(1): 654, 2023 02 14.
Article en En | MEDLINE | ID: mdl-36788215
Stunting affects one-in-five children globally and is associated with greater infectious morbidity, mortality and neurodevelopmental deficits. Recent evidence suggests that the early-life gut microbiome affects child growth through immune, metabolic and endocrine pathways. Using whole metagenomic sequencing, we map the assembly of the gut microbiome in 335 children from rural Zimbabwe from 1-18 months of age who were enrolled in the Sanitation, Hygiene, Infant Nutrition Efficacy Trial (SHINE; NCT01824940), a randomized trial of improved water, sanitation and hygiene (WASH) and infant and young child feeding (IYCF). Here, we show that the early-life gut microbiome undergoes programmed assembly that is unresponsive to the randomized interventions intended to improve linear growth. However, maternal HIV infection is associated with over-diversification and over-maturity of the early-life gut microbiome in their uninfected children, in addition to reduced abundance of Bifidobacterium species. Using machine learning models (XGBoost), we show that taxonomic microbiome features are poorly predictive of child growth, however functional metagenomic features, particularly B-vitamin and nucleotide biosynthesis pathways, moderately predict both attained linear and ponderal growth and growth velocity. New approaches targeting the gut microbiome in early childhood may complement efforts to combat child undernutrition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Infant Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Infant Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido