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Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial.
Rijpma, Danielle; Pijpe, Anouk; Claes, Karel; Hoeksema, Henk; de Decker, Ignace; Verbelen, Jozef; van Zuijlen, Paul; Monstrey, Stan; Meij-de Vries, Annebeth.
Afiliación
  • Rijpma D; Burn Center, Red Cross Hospital, Beverwijk, The Netherlands.
  • Pijpe A; Amsterdam UMC Location Vrije Universiteit Amsterdam, Plastic, Reconstructive and Hand Surgery, Amsterdam, The Netherlands.
  • Claes K; Association of Dutch Burn Centers, Burn Center, Red Cross Hospital, Beverwijk, The Netherlands.
  • Hoeksema H; Burn Center, Red Cross Hospital, Beverwijk, The Netherlands.
  • de Decker I; Amsterdam UMC Location Vrije Universiteit Amsterdam, Plastic, Reconstructive and Hand Surgery, Amsterdam, The Netherlands.
  • Verbelen J; Association of Dutch Burn Centers, Burn Center, Red Cross Hospital, Beverwijk, The Netherlands.
  • van Zuijlen P; Department of Plastic Surgery, Ghent University Hospital, Ghent, Belgium.
  • Monstrey S; Ghent Burn Center, Ghent University Hospital, Ghent, Belgium.
  • Meij-de Vries A; Department of Plastic Surgery, Ghent University Hospital, Ghent, Belgium.
PLoS One ; 18(2): e0281347, 2023.
Article en En | MEDLINE | ID: mdl-36787292
INTRODUCTION: Autologous split thickness skin grafting is the standard-of-care for most deep dermal and full thickness skin defects. Historically, mesh grafting is used to expand skin grafts for smaller defects and other techniques such as Meek micrografting is used to enable expansion for larger skin defects. Yet, Meek micrografting is increasingly used for smaller skin defects as well. Both techniques are frequently used, especially in burn centers, but evidence on which one is preferable for relative smaller skin defects is lacking. Therefore, an intra-patient randomized controlled trial was designed to adequately compare multiple outcomes of the Meek micrografting and mesh grafting techniques. MATERIALS AND METHODS: A multicenter intra-patient controlled randomized trial is being performed in two burn centers (the Netherlands and Belgium) to compare multiple outcomes of Meek micrografting and mesh grafting burns or skin defects. Study registration number (NL74274.029.20). Adult patients with a (burn) wound and an indication for surgical excision and skin grafting were screened for inclusion. In total 70 patients will be included and the primary outcome is scar quality twelve months post-surgery assessed by the Patient and Observer Scar Assessment Scale. Moreover, graft take, re-epithelialization, infection rate, donor site size and patients' preference are also measured within hospital admission, on 3 months and 12 months post-surgery. DISCUSSION: This is the first randomized trial that is intra-patient controlled, which enables a proper comparison between both skin expansion techniques. The results of this study will contribute to the clarification of the indications of both techniques and ample attention is paid for the patients' opinion on the surgical treatment options.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mallas Quirúrgicas / Cicatriz Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mallas Quirúrgicas / Cicatriz Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos