Discovery of Novel <i>N</i>-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.

Yang, Kan; Nong, Keyi; Xu, Fei; Chen, Yu; Yu, Jinying; Lin, Lizhi; Hu, Xiao; Wang, Youzhi; Li, Ting; Dong, Jibin; Wang, Jinxin

Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.

Yang, Kan; Nong, Keyi; Xu, Fei; Chen, Yu; Yu, Jinying; Lin, Lizhi; Hu, Xiao; Wang, Youzhi; Li, Ting; Dong, Jibin; Wang, Jinxin.

Afiliación

Yang K; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Nong K; Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
Xu F; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Chen Y; State Key Laboratory of Coordination Chemistry and Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
Yu J; Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Lin L; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Hu X; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Wang Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Li T; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Dong J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Wang J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

J Med Chem ; 66(4): 2681-2698, 2023 02 23.

Article en En | MEDLINE | ID: mdl-36786607

Asunto(s)

Aterosclerosis; Esfingomielina Fosfodiesterasa; Ratones; Humanos; Animales; Ceramidas; Aorta; Aorta Torácica

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Aterosclerosis Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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