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Three New Selaginellin Derivatives from Selaginella pulvinata and Their α-Glucosidase Inhibitory Activity.
Zhu, Qin-Feng; Luo, Tian-Tian; Chen, Qian; Gao, Bei-Bei; Zeng, Ai-Fen; Ao, Jun-Li; Xu, Guo-Bo; Liao, Shang-Gao; He, Xun.
Afiliación
  • Zhu QF; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
  • Luo TT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Chen Q; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
  • Gao BB; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
  • Zeng AF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Ao JL; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
  • Xu GB; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
  • Liao SG; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
  • He X; School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 550025, Guiyang, P. R. China.
Chem Biodivers ; 20(4): e202300109, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36786210
Three new selaginellin derivatives, selaginpulvilins V-X (1-3), together with seven known analogs (4-10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR-ESI-MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol-trimmed skeleton. Biological evaluation showed that compounds 2, 6 and 8 displayed moderate inhibition against α-glucosidase with IC50 values of 3.71, 2.04 and 4.00 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selaginellaceae Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selaginellaceae Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article Pais de publicación: Suiza