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Short-term associations between ambient air pollution and emergency department visits for Alzheimer's disease and related dementias.
Zhang, Haisu; Shi, Liuhua; Ebelt, Stefanie T; D'Souza, Rohan R; Schwartz, Joel D; Scovronick, Noah; Chang, Howard H.
Afiliación
  • Zhang H; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Shi L; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Ebelt ST; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • D'Souza RR; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Schwartz JD; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Scovronick N; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Chang HH; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Environ Epidemiol ; 7(1): e237, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36777523
Dementia is a seriously disabling illness with substantial economic and social burdens. Alzheimer's disease and its related dementias (AD/ADRD) constitute about two-thirds of dementias. AD/ADRD patients have a high prevalence of comorbid conditions that are known to be exacerbated by exposure to ambient air pollution. Existing studies mostly focused on the long-term association between air pollution and AD/ADRD morbidity, while very few have investigated short-term associations. This study aims to estimate short-term associations between AD/ADRD emergency department (ED) visits and three common air pollutants: fine particulate matter (PM2.5), nitrogen dioxide (NO2), and warm-season ozone. Methods: For the period 2005 to 2015, we analyzed over 7.5 million AD/ADRD ED visits in five US states (California, Missouri, North Carolina, New Jersey, and New York) using a time-stratified case-crossover design with conditional logistic regression. Daily estimated PM2.5, NO2, and warm-season ozone concentrations at 1 km spatial resolution were aggregated to the ZIP code level as exposure. Results: The most consistent positive association was found for NO2. Across five states, a 17.1 ppb increase in NO2 concentration over a 4-day period was associated with a 0.61% (95% confidence interval = 0.27%, 0.95%) increase in AD/ADRD ED visits. For PM2.5, a positive association with AD/ADRD ED visits was found only in New York (0.64%, 95% confidence interval = 0.26%, 1.01% per 6.3 µg/m3). Associations with warm-season ozone levels were null. Conclusions: Our results suggest AD/ADRD patients are vulnerable to short-term health effects of ambient air pollution and strategies to lower exposure may reduce morbidity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Environ Epidemiol Año: 2023 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Environ Epidemiol Año: 2023 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos