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Two-Year observational study of autonomic skin function in patients with Parkinson's disease compared to healthy individuals.
Siepmann, Timo; Arndt, Martin; Sedghi, Annahita; Szatmári, Szabolcs; Horváth, Tamás; Takáts, Annamária; Bereczki, Dániel; Moskopp, Mats Leif; Buchmann, Sylvia; Skowronek, Cornelia; Zago, Wagner; Woranush, Warunya; Lapusca, Razvan; Weidemann, Marie Luise; Gibbons, Christopher H; Freeman, Roy; Reichmann, Heinz; Puetz, Volker; Barlinn, Kristian; Pintér, Alexandra; Illigens, Ben Min-Woo.
Afiliación
  • Siepmann T; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Arndt M; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Sedghi A; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Szatmári S; Department of Neurology, Semmelweis University, Budapest, Hungary.
  • Horváth T; Research Center for Sport Physiology, Hungarian University of Sports Science, Budapest, Hungary.
  • Takáts A; Department of Neurology, Semmelweis University, Budapest, Hungary.
  • Bereczki D; Department of Neurology, Semmelweis University, Budapest, Hungary.
  • Moskopp ML; Department of Neurosurgery, Vivantes Klinikum im Friedrichshain, Berlin, Germany.
  • Buchmann S; Institute of Physiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Skowronek C; Department of Anesthesiology, Vivantes Klinikum Neukölln, Berlin, Germany.
  • Zago W; Department of Neurology, Charité University Medicine Berlin, Berlin, Germany.
  • Woranush W; Prothena Biosciences, South San Francisco, California, USA.
  • Lapusca R; Institute of Physiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Weidemann ML; Heart Center Leipzig, Leipzig, Germany.
  • Gibbons CH; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Freeman R; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
  • Reichmann H; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
  • Puetz V; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Barlinn K; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Pintér A; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Illigens BM; Department of Family Medicine, Semmelweis University, Budapest, Hungary.
Eur J Neurol ; 30(5): 1281-1292, 2023 05.
Article en En | MEDLINE | ID: mdl-36773001
BACKGROUND AND PURPOSE: We characterized autonomic pilomotor and sudomotor skin function in early Parkinson's disease (PD) longitudinally. METHODS: We enrolled PD patients (Hoehn and Yahr 1-2) and healthy controls from movement disorder centers in Germany, Hungary, and the United States. We evaluated axon-reflex responses in adrenergic sympathetic pilomotor nerves and in cholinergic sudomotor nerves and assessed sympathetic skin response (SSR), predominantly parasympathetic neurocardiac function via heart rate variability, and disease-related symptoms at baseline, after 2 weeks, and after 1 and 2 years. CLINICALTRIALS: gov: NCT03043768. RESULTS: We included 38 participants: 26 PD (60% females, aged 62.4 ± 7.4 years, mean ± SD) and 12 controls (75% females, aged 59.5 ± 5.8 years). Pilomotor function was reduced in PD compared to controls at baseline when quantified via spatial axon-reflex spread (78 [43-143], median [interquartile range] mm2 vs. 175 [68-200] mm2 , p = 0.01) or erect hair follicle count in the axon-reflex region (8 [6-10] vs. 11 [6-16], p = 0.008) and showed reliability absent any changes from baseline to Week 2 (p = not significant [ns]). Between-group differences increased over the course of 2 years (p < 0.05), although no decline was observed within groups (p = ns). Pilomotor impairment in PD correlated with motor symptoms (rho = -0.59, p = 0.017) and was not lateralized (p = ns). Sudomotor axon-reflex and neurocardiac function did not differ between groups (p = ns), but SSR was reduced in PD (p = 0.0001). CONCLUSIONS: Impairment of adrenergic sympathetic pilomotor function and SSR in evolving PD is not paralleled by changes to cholinergic sudomotor function and parasympathetic neurocardiac function, suggesting a sympathetic pathophysiology. A pilomotor axon-reflex test might be useful to monitor PD-related pathology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Enfermedades del Sistema Nervioso Autónomo Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Enfermedades del Sistema Nervioso Autónomo Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido