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Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives.
Clayton-Chubb, Daniel; Kemp, William; Majeed, Ammar; Lubel, John S; Hodge, Alex; Roberts, Stuart K.
Afiliación
  • Clayton-Chubb D; Department of Gastroenterology, The Alfred Hospital, Melbourne, VIC 3004, Australia.
  • Kemp W; Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
  • Majeed A; Department of Gastroenterology, The Alfred Hospital, Melbourne, VIC 3004, Australia.
  • Lubel JS; Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
  • Hodge A; Department of Gastroenterology, The Alfred Hospital, Melbourne, VIC 3004, Australia.
  • Roberts SK; Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Nutrients ; 15(3)2023 Jan 29.
Article en En | MEDLINE | ID: mdl-36771394
While non-alcoholic fatty liver disease (NAFLD) is a prevalent and frequent cause of liver-related morbidity and mortality, it is also strongly associated with cardiovascular disease-related morbidity and mortality, likely driven by its associations with insulin resistance and other manifestations of metabolic dysregulation. However, few satisfactory pharmacological treatments are available for NAFLD due in part to its complex pathophysiology, and challenges remain in stratifying individual patient's risk for liver and cardiovascular disease related outcomes. In this review, we describe the development and progression of NAFLD, including its pathophysiology and outcomes. We also describe different tools for identifying patients with NAFLD who are most at risk of liver-related and cardiovascular-related complications, as well as current and emerging treatment options, and future directions for research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Enfermedades Cardiovasculares / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Enfermedades Cardiovasculares / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza