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Tumors of the Nose and Paranasal Sinuses: Promoting Factors and Molecular Mechanisms-A Systematic Review.
Lucidi, Daniela; Cantaffa, Carla; Miglio, Matteo; Spina, Federica; Alicandri Ciufelli, Matteo; Marchioni, Alessandro; Marchioni, Daniele.
Afiliación
  • Lucidi D; Department of Otolaryngology, Head and Neck Surgery, University Hospital of Modena, 41124 Modena, Italy.
  • Cantaffa C; Department of Otolaryngology, Head and Neck Surgery, University Hospital of Modena, 41124 Modena, Italy.
  • Miglio M; Department of Otolaryngology, Head and Neck Surgery, University Hospital of Modena, 41124 Modena, Italy.
  • Spina F; Department of Otolaryngology, Head and Neck Surgery, University Hospital of Modena, 41124 Modena, Italy.
  • Alicandri Ciufelli M; Department of Otolaryngology, Head and Neck Surgery, University Hospital of Modena, 41124 Modena, Italy.
  • Marchioni A; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, 41124 Modena, Italy.
  • Marchioni D; Department of Otolaryngology, Head and Neck Surgery, University Hospital of Modena, 41124 Modena, Italy.
Int J Mol Sci ; 24(3)2023 Jan 31.
Article en En | MEDLINE | ID: mdl-36768990
Sinonasal neoplasms are uncommon diseases, characterized by heterogeneous biological behavior, which frequently results in challenges in differential diagnosis and treatment choice. The aim of this review was to examine the pathogenesis and molecular mechanisms underlying the regulation of tumor initiation and growth, in order to better define diagnostic and therapeutic strategies as well as the prognostic impact of these rare neoplasms. A systematic review according to Preferred Reporting Items for Systematic Review and Meta-Analysis criteria was conducted between September and November 2022. The authors considered the three main histological patterns of sinonasal tumors, namely Squamous Cell Carcinoma, Intestinal-Type Adenocarcinoma, and Olfactory Neuroblastoma. In total, 246 articles were eventually included in the analysis. The genetic and epigenetic changes underlying the oncogenic process were discussed, through a qualitative synthesis of the included studies. The identification of a comprehensive model of carcinogenesis for each sinonasal cancer subtype is needed, in order to pave the way toward tailored treatment approaches and improve survival for this rare and challenging group of cancers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senos Paranasales / Neoplasias de los Senos Paranasales / Carcinoma de Células Escamosas / Adenocarcinoma / Neoplasias Nasales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senos Paranasales / Neoplasias de los Senos Paranasales / Carcinoma de Células Escamosas / Adenocarcinoma / Neoplasias Nasales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza