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Monomeric C-Reactive Protein in Atherosclerotic Cardiovascular Disease: Advances and Perspectives.
Melnikov, Ivan; Kozlov, Sergey; Saburova, Olga; Avtaeva, Yuliya; Guria, Konstantin; Gabbasov, Zufar.
Afiliación
  • Melnikov I; National Medical Research Centre of Cardiology Named after Academician E.I. Chazov, Ministry of Health of the Russian Federation, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia.
  • Kozlov S; State Research Center of the Russian Federation, Institute of Biomedical Problems of Russian Academy of Sciences, 76A Khoroshevskoye Shosse, 123007 Moscow, Russia.
  • Saburova O; National Medical Research Centre of Cardiology Named after Academician E.I. Chazov, Ministry of Health of the Russian Federation, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia.
  • Avtaeva Y; National Medical Research Centre of Cardiology Named after Academician E.I. Chazov, Ministry of Health of the Russian Federation, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia.
  • Guria K; National Medical Research Centre of Cardiology Named after Academician E.I. Chazov, Ministry of Health of the Russian Federation, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia.
  • Gabbasov Z; National Medical Research Centre of Cardiology Named after Academician E.I. Chazov, Ministry of Health of the Russian Federation, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia.
Int J Mol Sci ; 24(3)2023 Jan 20.
Article en En | MEDLINE | ID: mdl-36768404
This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the final product of the interleukin (IL)-1ß/IL-6/CRP axis. Its monomeric form can be produced at sites of local inflammation through the dissociation of pentameric CRP and, to some extent, local synthesis. mCRP has a distinct proinflammatory profile. In vitro and animal-model studies have suggested a role for mCRP in: platelet activation, adhesion, and aggregation; endothelial activation; leukocyte recruitment and polarization; foam-cell formation; and neovascularization. mCRP has been shown to deposit in atherosclerotic plaques and damaged tissues. In recent years, the first published papers have reported the development and application of mCRP assays. Principally, these studies demonstrated the feasibility of measuring mCRP levels. With recent advances in detection techniques and the introduction of first assays, mCRP-level measurement should become more accessible and widely used. To date, anti-inflammatory therapy in atherosclerosis has targeted the NLRP3 inflammasome and upstream links of the IL-1ß/IL-6/CRP axis. Large clinical trials have provided sufficient evidence to support this strategy. However, few compounds target CRP. Studies on these agents are limited to animal models or small clinical trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Aterosclerosis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Aterosclerosis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza