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Benzene Exposure and MicroRNAs Expression: In Vitro, In Vivo and Human Findings.
Mozzoni, Paola; Poli, Diana; Pinelli, Silvana; Tagliaferri, Sara; Corradi, Massimo; Cavallo, Delia; Ursini, Cinzia Lucia; Pigini, Daniela.
Afiliación
  • Mozzoni P; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
  • Poli D; CERT, Center of Excellent Research in Toxicology, University of Parma, 43126 Parma, Italy.
  • Pinelli S; INAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via Fontana Candida, 1, 00078 Monte Porzio Catone, Italy.
  • Tagliaferri S; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
  • Corradi M; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
  • Cavallo D; CERT, Center of Excellent Research in Toxicology, University of Parma, 43126 Parma, Italy.
  • Ursini CL; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
  • Pigini D; CERT, Center of Excellent Research in Toxicology, University of Parma, 43126 Parma, Italy.
Int J Environ Res Public Health ; 20(3)2023 01 20.
Article en En | MEDLINE | ID: mdl-36767288
MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on human health is established and interest in them is progressively increasing. Environmental and occupational risk factors affecting human health include chemical agents. Benzene represents a pollutant of concern due to its ubiquity and because it may alter gene expression by epigenetic mechanisms, including miRNA expression changes. This review summarizes recent findings on miRNAs associated with benzene exposure considering in vivo, in vitro and human findings in order to better understand the molecular mechanisms through which benzene induces toxic effects and to evaluate whether selected miRNAs may be used as biomarkers associated with benzene exposure. Original research has been included and the study selection, data extraction and assessments agreed with PRISMA criteria. Both in vitro studies and human results showed a variation in miRNAs' expression after exposure to benzene. In vivo surveys also exhibited this trend, but they cannot be regarded as conclusive because of their small number. However, this review confirms the potential role of miRNAs as "early warning" signals in the biological response induced by exposure to benzene. The importance of identifying miRNAs' expression, which, once validated, might work as sentinel molecules to better understand the extent of the exposure to xenobiotics, is clear. The identification of miRNAs as a molecular signature associated with specific exposure would be advantageous for disease prevention and health promotion in the workplace.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Contaminantes Ambientales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Contaminantes Ambientales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza