Pharmacological Targeting of the RAGE-NF&#954;B Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function.

Dorenkamp, Marc; Nasiry, Madina; Semo, Dilvin; Koch, Sybille; Löffler, Ivonne; Wolf, Gunter; Reinecke, Holger; Godfrey, Rinesh

Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function.

Dorenkamp, Marc; Nasiry, Madina; Semo, Dilvin; Koch, Sybille; Löffler, Ivonne; Wolf, Gunter; Reinecke, Holger; Godfrey, Rinesh.

Afiliación

Dorenkamp M; Vascular Signalling, Molecular Cardiology, Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Nasiry M; Vascular Signalling, Molecular Cardiology, Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Semo D; Vascular Signalling, Molecular Cardiology, Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Koch S; Vascular Signalling, Molecular Cardiology, Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Löffler I; Department of Internal Medicine III, University Hospital Jena, 07743 Jena, Germany.
Wolf G; Department of Internal Medicine III, University Hospital Jena, 07743 Jena, Germany.
Reinecke H; Vascular Signalling, Molecular Cardiology, Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Godfrey R; Vascular Signalling, Molecular Cardiology, Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.

Cells ; 12(3)2023 02 03.

Article en En | MEDLINE | ID: mdl-36766855

Asunto(s)

Diabetes Mellitus Tipo 2; Animales; Humanos; Ratones; Diabetes Mellitus Tipo 2/metabolismo; Productos Finales de Glicación Avanzada/metabolismo; Inflamación/metabolismo; Monocitos/metabolismo; FN-kappa B/metabolismo; Proteína Tirosina Fosfatasa no Receptora Tipo 11/metabolismo; Receptor para Productos Finales de Glicación Avanzada/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

NFκB; PTPN11; RAGE; SHP-2; T2DM; atherosclerosis; methylglyoxal; monocytes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cells Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza

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