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A Suggested Modification to FIGO Stage IV Epithelial Ovarian Cancer.
Métairie, Marie; Benoit, Louise; Koual, Meriem; Bentivegna, Enrica; Wohrer, Henri; Bolze, Pierre-Adrien; Kerbage, Yohan; Raimond, Emilie; Akladios, Cherif; Carcopino, Xavier; Canlorbe, Geoffroy; Uzan, Jennifer; Lavoué, Vincent; Mimoun, Camille; Huchon, Cyrille; Koskas, Martin; Costaz, Hélène; Margueritte, François; Dabi, Yohann; Touboul, Cyril; Bendifallah, Sofiane; Ouldamer, Lobna; Delanoy, Nicolas; Nguyen-Xuan, Huyen-Thu; Bats, Anne-Sophie; Azaïs, Henri.
Afiliación
  • Métairie M; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological Oncological and Breast Surgery, Hôpital Européen Georges-Pompidou, 75015 Paris, France.
  • Benoit L; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological Oncological and Breast Surgery, Hôpital Européen Georges-Pompidou, 75015 Paris, France.
  • Koual M; INSERM UMR-S 1124, University of Paris Cité, Centre Universitaire des Saints-Pères, 75006 Paris, France.
  • Bentivegna E; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological Oncological and Breast Surgery, Hôpital Européen Georges-Pompidou, 75015 Paris, France.
  • Wohrer H; INSERM UMR-S 1124, University of Paris Cité, Centre Universitaire des Saints-Pères, 75006 Paris, France.
  • Bolze PA; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological Oncological and Breast Surgery, Hôpital Européen Georges-Pompidou, 75015 Paris, France.
  • Kerbage Y; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological Oncological and Breast Surgery, Hôpital Européen Georges-Pompidou, 75015 Paris, France.
  • Raimond E; Department of Gynaecologic and Oncologic Surgery and Obstetrics, Lyon Sud University Hospital, Hospices Civils de Lyon, Université Lyon 1, 69002 Lyon, France.
  • Akladios C; CHU Lille, Department of Gynaecologic Surgery, University Lille, 59000 Lille, France.
  • Carcopino X; Department of Obstetrics and Gynaecology, Institute Alix de Champagne University Hospital, 51100 Reims, France.
  • Canlorbe G; Department of Gynaecology, Hôpitaux Universitaires de Strasbourg, 67200 Strasbourg, France.
  • Uzan J; Department of Obstetrics and Gynaecology, Hôpital Nord, APHM, Aix-Marseille University (AMU), University Avignon, CNRS, IRD, IMBE, UMR 7263, 13397 Marseille, France.
  • Lavoué V; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological and Breast Surgery and Oncology, Pitié-Salpêtrière, 75013 Paris, France.
  • Mimoun C; Centre de Recherche Saint-Antoine (CRSA), INSERM UMR_S_938, Cancer Biology and Therapeutics, Sorbonne University, 75012 Paris, France.
  • Huchon C; University Institute of Cancer, Sorbonne University, 75013 Paris, France.
  • Koskas M; Department of Obstetrics Gynecology and Reproductive Medicine, University Paris Est Créteil, Centre Hospitalier Intercommunal de Créteil, 94000 Créteil, France.
  • Costaz H; Department of Gynaecological Surgery, INSERM U1085, équipe 8, CRLC Eugène Marquis, Université de Rennes 1, Hôpital Sud, CHU de Rennes, 35000 Rennes, France.
  • Margueritte F; Department of Gynaecological Oncological and Breast Surgery-Université de Paris, Hôpital Lariboisière, 75010 Paris, France.
  • Dabi Y; Department of Gynaecological Oncological and Breast Surgery-Université de Paris, Hôpital Lariboisière, 75010 Paris, France.
  • Touboul C; AP-HP (Assistance Publique des Hôpitaux de Paris), Division of Gynaecologic Oncology, Bichat University Hospital, 75018 Paris, France.
  • Bendifallah S; Department of Surgical Oncology, Georges-François Leclerc Centre, 21000 Dijon, France.
  • Ouldamer L; Department of Gynaecology, Centre Hospitalier Intercommunal de Poissy-Saint-Germain-en-laye, Site Hospitalier de Poissy, 78498 Poissy, France.
  • Delanoy N; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecology ans Obstetrics, Hôpital Tenon, 75020 Paris, France.
  • Nguyen-Xuan HT; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecology ans Obstetrics, Hôpital Tenon, 75020 Paris, France.
  • Bats AS; AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecology ans Obstetrics, Hôpital Tenon, 75020 Paris, France.
  • Azaïs H; Department of Gynaecology, Hôpital Universitaire de Tours, 37000 Tours, France.
Cancers (Basel) ; 15(3)2023 Jan 24.
Article en En | MEDLINE | ID: mdl-36765667
International Federation of Gynecology and Obstetrics (FIGO) staging classification for stage IV epithelial ovarian cancer (EOC) separates stages IVA (pleural effusion) and IVB (parenchymal and/or extra-abdominal lymph node metastases). We aimed to evaluate its prognostic impact and to compare survival according to the initial metastatic location. We conducted a multicenter study between 2000 and 2020, including patients with a FIGO stage IV EOC. Primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS) and recurrence rates. We included 307 patients: 98 (32%) had FIGO stage IVA and 209 (68%) had FIGO stage IVB. The median OS and PFS of stage IVA patients were significantly lower than those of stage IVB patients (31 versus 45 months (p = 0.02) and 18 versus 25 months (p = 0.01), respectively). Recurrence rate was higher in stage IVA than IVB patients (65% versus 47% (p = 0.004)). Initial pleural involvement was a poor prognostic factor with a median OS of 35 months versus 49 months for patients without initial pleural involvement (p = 0.024). Patients with FIGO stage IVA had a worse prognosis than patients with FIGO stage IVB EOC. Pleural involvement appears to be relevant for predicting survival. We suggest a modification of the current FIGO staging classification.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza