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Two new alkaloids from the endophytic fungus Schizophyllum sp. HM230 isolated from Vincetoxicum mongolicum Maxim.
Li, Zhuang; Zhang, Bing-Wen; Jiang, Li; Wang, He; Ma, Qing-Yun; Wang, Hong-Fei; Zhang, Jun; Chen, Feng-Li; Zhao, You-Xing; Luo, Du-Qiang.
Afiliación
  • Li Z; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Zhang BW; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Jiang L; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Wang H; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Ma QY; Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China.
  • Wang HF; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Zhang J; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Chen FL; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
  • Zhao YX; Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China.
  • Luo DQ; College of Life Science, Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding, People's Republic of China.
Nat Prod Res ; : 1-8, 2023 Feb 10.
Article en En | MEDLINE | ID: mdl-36762731
Endophytic fungi is an important source for the discovery of bioactive natural compounds. A chemical investigation of the ethyl acetate extract of the endophytic fungus Schizophyllum sp. HM230 derived from stems of the herb Vincetoxicum mongolicum Maxim led to isolation of five alkaloids, including two new compounds, schizophyllins M (1) and N (2), along with three known ones (3-5). The planar structures of two new compounds were elucidated by extensive spectroscopic methods including MS, 1D and 2D NMR. Their absolute configurations were determined by Mosher's method and comparison of the ECD data. All the isolates were evaluated for their cytotoxicity and antioxidant activities. Compounds 1-4 showed middle cytotoxicity against MCF-7 cells with IC50 values range of 68.1 ∼ 87.32 µM. Compounds 1-5 displayed obvious antioxidant activity with the IC50 values range of 0.86 ∼ 5.78 mg/mL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido