Your browser doesn't support javascript.
loading
Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease.
Frederiksen, Kristian Steen; Jensen, Camilla Steen; Høgh, Peter; Gergelyffy, Robert; Waldemar, Gunhild; Andersen, Birgitte Bo; Gottrup, Hanne; Vestergaard, Karsten; Wermuth, Lene; Søndergaard, Helle Bach; Sellebjerg, Finn; Hasselbalch, Steen Gregers; Simonsen, Anja Hviid.
Afiliación
  • Frederiksen KS; Department of Neurology, Danish Dementia Research Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Jensen CS; Department of Neurology, Danish Dementia Research Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Høgh P; Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Gergelyffy R; Department of Clinical Medicine, Regional Dementia Research Centre, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Waldemar G; Department of Geriatrics, Slagelse Hospital, Slagelse, Denmark.
  • Andersen BB; Department of Neurology, Danish Dementia Research Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Gottrup H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Vestergaard K; Department of Neurology, Danish Dementia Research Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Wermuth L; Dementia Clinic, Aarhus University Hospital, Aarhus, Denmark.
  • Søndergaard HB; Dementia Clinic, Aalborg University Hospital, Aalborg, Denmark.
  • Sellebjerg F; Department of Neurology, Dementia Clinic, Slagelse Hospital, Slagelse, Denmark.
  • Hasselbalch SG; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
  • Simonsen AH; Danish Multiple Sclerosis Center, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
Front Neurosci ; 17: 1108191, 2023.
Article en En | MEDLINE | ID: mdl-36761410
Introduction: Aerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration. Objective: To investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer's disease (AD). Methods: This is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer's disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention. Results: A total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOEε4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline -1.16, p = 0.09]. Conclusion: The findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration. Clinical trial registration: clinicaltrials.gov, identifier NCT01681602.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Front Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Front Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza