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Epimedii Folium and Ligustri Lucidi Fructus Promote Osteoblastogenesis and Inhibit Osteoclastogenesis against Osteoporosis via Acting on Osteoblast-Osteoclast Communication.
Ma, Zitong; Tang, Xiufeng; Chen, Yuheng; Wang, Han; Li, Yuman; Long, Yuting; Liu, Renhui.
Afiliación
  • Ma Z; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
  • Tang X; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
  • Chen Y; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
  • Wang H; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
  • Li Y; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
  • Long Y; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
  • Liu R; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Oxid Med Cell Longev ; 2023: 7212642, 2023.
Article en En | MEDLINE | ID: mdl-36760348
Osteoblast (OB) and osteoclast (OC) play important roles in bone formation and bone resorption, which can communicate with each other through cytokine paracrine. Previous studies have confirmed that Epimedii Folium (EF) and Ligustri Lucidi Fructus (LLF) used alone or in combination can treat osteoporosis (OP) through regulating bone remodeling, but the effects of EF and LLF on osteoblastogenesis, osteoclastogenesis, and OB-OC communication are unclear. In this study, we investigated the direct and indirect effects of EF and LLF on OBs and OCs via monoculture and coculture (transwell) models of OBs and OCs. We found that the combination of EF and LLF (EF&LLF) could promote osteoblastogenesis and inhibit osteoclastogenesis directly and indirectly. In order to study the mechanisms of EF&LLF on indirectly regulating osteoblastogenesis and osteoclastogenesis, we detected the expression of cytokines by which OBs and OCs could communicate with each other. We found that EF&LLF could downregulate the expression of RANKL and M-CSF and the protein ratio of RANKL/OPG of OBs and Atp6v0d2 expression of OCs and upregulate the expression of OPG and TGF-ß1 of OBs and the expression of TGF-ß1, BMP-2, and IGF-1 of OCs, indicating that EF&LLF could regulate cytokine expressions of OBs/OCs to affect OB-OC communication. In addition, EF&LLF had a better effect on regulating cytokines of OBs and OCs than EF or LLF in single use. This study suggested that EF&LLF exhibited the effects of promoting osteoblastogenesis and inhibiting osteoclastogenesis via acting on OB-OC communication and provided some scientific evidences for EF&LLF against OP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Ligustrum Tipo de estudio: Prognostic_studies Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Ligustrum Tipo de estudio: Prognostic_studies Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos