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SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses.
Christensen, Dennis; Polacek, Charlotta; Sheward, Daniel J; Hanke, Leo; McInerney, Gerald; Murrell, Ben; Hartmann, Katrine Top; Jensen, Henrik Elvang; Zimmermann, Julie; Jungersen, Gregers; Illigen, Kristin Engelhart; Isling, Louise Krag; Fernandez-Antunez, Carlota; Ramirez, Santseharay; Bukh, Jens; Pedersen, Gabriel Kristian.
Afiliación
  • Christensen D; Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
  • Polacek C; Virus Research and Development Laboratory, Department of Microbial Diagnostic and Virology, Statens Serum Institut, Copenhagen, Denmark.
  • Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Hanke L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • McInerney G; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Hartmann KT; Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Jensen HE; Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Zimmermann J; Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
  • Jungersen G; Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
  • Illigen KE; Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
  • Isling LK; Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
  • Fernandez-Antunez C; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark.
  • Ramirez S; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Bukh J; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark.
  • Pedersen GK; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Front Immunol ; 14: 941281, 2023.
Article en En | MEDLINE | ID: mdl-36756130
SARS-CoV-2 continues to pose a threat to human health as new variants emerge and thus a diverse vaccine pipeline is needed. We evaluated SARS-CoV-2 HexaPro spike protein formulated in Alhydrogel® (aluminium oxyhydroxide) in Syrian hamsters, using an accelerated two dose regimen (given 10 days apart) and a standard regimen (two doses given 21 days apart). Both regimens elicited spike- and RBD-specific IgG antibody responses of similar magnitude, but in vitro virus neutralization was low or undetectable. Despite this, the accelerated two dose regimen offered reduction in viral load and protected against lung pathology upon challenge with homologous SARS-CoV-2 virus (Wuhan-Hu-1). This highlights that vaccine-induced protection against SARS-CoV-2 disease can be obtained despite low neutralizing antibody levels and suggests that accelerated vaccine schedules may be used to confer rapid protection against SARS-CoV-2 disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza