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Analysis of the genomic landscape of inbreeding in two divergent groups of Spanish Florida goats.
Ziegler, Tatiana E; Molina, Antonio; Ramón, Manuel; Sanchez, Manuel; Muñoz-Mejías, Eva; Antonini, Alicia; Demyda-Peyrás, Sebastián.
Afiliación
  • Ziegler TE; IGEVET - Instituto de Genética Veterinaria "Ing. Fernando N. Dulout" (UNLP-CONICET LA PLATA), Facultad de Ciencias Veterinarias UNLP, La Plata, Argentina.
  • Molina A; Departamento de Genética, Universidad de Córdoba, Córdoba, Spain.
  • Ramón M; IRIAF-CERSYRA - Instituto Regional de Investigación y Desarrollo Agroalimentario y Forestal, Centro Regional de Selección y Reproducción Animal, Ciudad Real, Spain.
  • Sanchez M; Departamento de Producción Animal, Universidad de Córdoba, Córdoba, Spain.
  • Muñoz-Mejías E; Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de los Alimentos, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
  • Antonini A; Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina.
  • Demyda-Peyrás S; Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina.
J Anim Breed Genet ; 140(3): 316-329, 2023 May.
Article en En | MEDLINE | ID: mdl-36751887
The analysis of the genomic landscape of inbreeding using runs of homozygosity (ROH) patterns is becoming an interesting tool to partially understand phenotypic differences among individuals. In this study, we analysed genome-wide ROH patterns in two groups of Florida goats. We first determined the inbreeding levels of each individual by calculating ROH-based inbreeding coefficients (FROH ). Then, the individuals were divided into two groups based on FROH : high inbreeding (HI, FROH >0.1) and low inbreeding (LI, FROH <0.03). Finally, we performed an extensive in-depth analysis of ROH distribution in each group separately. We found a higher abundance of short ROH in LI, whereas long ROH was more frequent in HI. Furthermore, ROH abundance was not evenly distributed among chromosomes within groups, with some chromosomes showing larger numbers of ROH, like CHI6, CHI7 and CHI27. A different landscape was observed in recent inbreeding (ROH >8 Mb), with significant increases in CHI6, CHI11 and CHI28. Determination of genomic regions with significantly increased ROH (ROH islands-ROHi) showed 13 ROHi related to whole inbreeding and five ROHi associated with recent inbreeding analysis. Within these genomic regions, 123 and 101 genes were identified in HI and LI, respectively, including 10 and seven candidate genes previously related to production, fertility and heat resistance in goats and livestock species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cabras / Endogamia Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: J Anim Breed Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cabras / Endogamia Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: J Anim Breed Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Alemania