Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models.

Langshaw, Emma L; Reynolds, Simone; Ozberk, Victoria; Dooley, Jessica; Calcutt, Ainslie; Zaman, Mehfuz; Walker, Mark J; Batzloff, Michael R; Davies, Mark R; Good, Michael F; Pandey, Manisha

Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models.

Langshaw, Emma L; Reynolds, Simone; Ozberk, Victoria; Dooley, Jessica; Calcutt, Ainslie; Zaman, Mehfuz; Walker, Mark J; Batzloff, Michael R; Davies, Mark R; Good, Michael F; Pandey, Manisha.

Afiliación

Langshaw EL; Institute for Glycomics, Griffith University, Queensland, Australia.
Reynolds S; Institute for Glycomics, Griffith University, Queensland, Australia.
Ozberk V; Institute for Glycomics, Griffith University, Queensland, Australia.
Dooley J; Institute for Glycomics, Griffith University, Queensland, Australia.
Calcutt A; Institute for Glycomics, Griffith University, Queensland, Australia.
Zaman M; Institute for Glycomics, Griffith University, Queensland, Australia.
Walker MJ; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Batzloff MR; Institute for Glycomics, Griffith University, Queensland, Australia.
Davies MR; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Good MF; Institute for Glycomics, Griffith University, Queensland, Australia.
Pandey M; Institute for Glycomics, Griffith University, Queensland, Australia.

mBio ; 14(1): e0348822, 2023 02 28.

Article en En | MEDLINE | ID: mdl-36744883

Asunto(s)

Infecciones Estreptocócicas; Streptococcus pyogenes; Animales; Ratones; Virulencia/genética; Estreptolisinas/genética; Estreptolisinas/metabolismo; Proteínas Bacterianas/metabolismo; Factores de Virulencia/metabolismo

Palabras clave

J8CombiVax; SLO; Streptococcus pyogenes; covR/S; dendritic cells; gene expression; neutrophils; skin infection; whole-genome sequencing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: MBio Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

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