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Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.
Ong, Han Wee; Truong, Anna; Kwarcinski, Frank; de Silva, Chandi; Avalani, Krisha; Havener, Tammy M; Chirgwin, Michael; Galal, Kareem A; Willis, Caleb; Krämer, Andreas; Liu, Shubin; Knapp, Stefan; Derbyshire, Emily R; Zutshi, Reena; Drewry, David H.
Afiliación
  • Ong HW; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Truong A; Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA.
  • Kwarcinski F; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
  • de Silva C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
  • Avalani K; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
  • Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Chirgwin M; Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA.
  • Galal KA; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Willis C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
  • Krämer A; Structural Genomics Consortium, Institute of Pharmaceutical Chemistry, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
  • Liu S; Research Computing Center, University of North Carolina, Chapel Hill, NC, 27599-3420, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC, 27599-3420, USA.
  • Knapp S; Structural Genomics Consortium, Institute of Pharmaceutical Chemistry, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
  • Derbyshire ER; Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, NC, 27710, USA. Electronic address: emily.derbyshire@duke.edu.
  • Zutshi R; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA. Electronic address: reena.zutshi@luceome.com.
  • Drewry DH; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Caro
Eur J Med Chem ; 249: 115043, 2023 Mar 05.
Article en En | MEDLINE | ID: mdl-36736152
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria Falciparum / Antimaláricos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
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Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria Falciparum / Antimaláricos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia