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Patterns of Extraneural Metastases in Children With Ependymoma.
Chan, Priya P; Whipple, Nicholas S; Ramani, Biswarathan; Solomon, David A; Zhou, Holly; Linscott, Luke L; Kestle, John R W; Bruggers, Carol S.
Afiliación
  • Chan PP; Departments of Pediatrics.
  • Whipple NS; Departments of Pediatrics.
  • Ramani B; Department of Pathology, University of California San Francisco, San Francisco, CA.
  • Solomon DA; Department of Pathology, University of California San Francisco, San Francisco, CA.
  • Zhou H; Pathology.
  • Linscott LL; Department of Radiology, Primary Children's Hospital, Salt Lake City, UT.
  • Kestle JRW; Neurosurgery, University of Utah.
  • Bruggers CS; Departments of Pediatrics.
J Pediatr Hematol Oncol ; 45(2): e272-e278, 2023 03 01.
Article en En | MEDLINE | ID: mdl-36730676
Ependymomas account for 10% of all malignant pediatric central nervous system tumors. Standard therapy includes maximal safe surgical resection, followed by focal radiation. Despite the aggressive therapy, progression-free survival is poor. Most ependymoma relapses occur locally at the original tumor site. Extraneural presentations of ependymoma are extremely rare, and no standard of care treatment exists. We present a single-institution case series of 3 patients who experienced extraneural relapses of supratentorial ependymoma and describe their treatment and outcome. These cases of extraneural relapse highlight the possible modes of extraneural spread, including hematogenous, lymphatic, and microscopic seeding through surgical drains and shunts. In addition, they illustrate the increase in histologic grade and mutational burden that may occur at the time of relapse. These cases illustrate the role of aggressive, individualized treatment interventions using a combination of surgery, radiation, and chemotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ependimoma / Recurrencia Local de Neoplasia Límite: Child / Humans Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ependimoma / Recurrencia Local de Neoplasia Límite: Child / Humans Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos