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Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.
Valitutti, Francesco; Leonard, Maureen M; Kenyon, Victoria; Montuori, Monica; Piemontese, Pasqua; Francavilla, Ruggiero; Malamisura, Basilio; Norsa, Lorenzo; Calvi, Angela; Lionetti, Maria Elena; Baldassarre, Mariella; Trovato, Chiara Maria; Perrone, Michela; Passaro, Tiziana; Sansotta, Naire; Crocco, Marco; Morelli, Annalisa; Raguseo, Lidia Celeste; Malerba, Federica; Elli, Luca; Cristofori, Fernanda; Catassi, Carlo; Fasano, Alessio.
Afiliación
  • Valitutti F; Pediatric Unit, "San Giovanni di Dio e Ruggi d'Aragona" University Hospital, Salerno, Italy.
  • Leonard MM; European Biomedical Research Institute of Salerno, Salerno, Italy.
  • Kenyon V; Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA.
  • Montuori M; Celiac Research Program, Harvard Medical School, Boston, Massachusetts, USA.
  • Piemontese P; Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA.
  • Francavilla R; Celiac Research Program, Harvard Medical School, Boston, Massachusetts, USA.
  • Malamisura B; Pediatric Gastroenterology Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
  • Norsa L; NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
  • Calvi A; Pediatric Unit "Bruno Trambusti," Osp Pediatrico Giovanni XXIII, University of Bari, Bari, Italy.
  • Lionetti ME; Celiac Disease Referral Center, "San Giovanni di Dio e Ruggi d'Aragona" University Hospital, Pole of Cava de' Tirreni, Salerno, Italy.
  • Baldassarre M; Pediatric Hepatology Gastroenterology and Transplant Unit, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy.
  • Trovato CM; Pediatrics, IRCCS Ospedale Giannina Gaslini, Genova, Italy.
  • Perrone M; Pediatrics, Univ. Politec. delle Marche, Ancona, Italy.
  • Passaro T; NICU, University of Bari, Bari, Italy.
  • Sansotta N; Celiac Disease Referral Center, Bambino Gesù Hospital, Rome, Italy.
  • Crocco M; NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
  • Morelli A; Celiac Disease Referral Center, "San Giovanni di Dio e Ruggi d'Aragona" University Hospital, Pole of Cava de' Tirreni, Salerno, Italy.
  • Raguseo LC; Pediatric Hepatology Gastroenterology and Transplant Unit, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy.
  • Malerba F; Pediatrics, IRCCS Ospedale Giannina Gaslini, Genova, Italy.
  • Elli L; Pediatric Training Program, University of Salerno School of Medicine, Salerno, Italy.
  • Cristofori F; Pediatric Unit "Bruno Trambusti," Osp Pediatrico Giovanni XXIII, University of Bari, Bari, Italy.
  • Catassi C; Pediatrics, IRCCS Ospedale Giannina Gaslini, Genova, Italy.
  • Fasano A; Celiac Disease Referral Center, Ospedale Maggiore Policlinico, Milan, Italy.
Am J Gastroenterol ; 118(3): 574-577, 2023 03 01.
Article en En | MEDLINE | ID: mdl-36727859
INTRODUCTION: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity). RESULTS: Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion. DISCUSSION: Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Am J Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Am J Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos