Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections.

Mora-Bitria, Laura; Asquith, Becca

Mora-Bitria, Laura; Asquith, Becca.

Afiliación

Mora-Bitria L; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Asquith B; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK. b.asquith@imperial.ac.uk.

Immunogenetics ; 75(3): 269-282, 2023 06.

Article en En | MEDLINE | ID: mdl-36719466

RESUMEN

Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction.

Asunto(s)

Linfocitos T; Virosis; Embarazo; Femenino; Humanos; Receptores KIR; Inmunidad Innata; Células Asesinas Naturales

Palabras clave

AICD; CD8 + T cells; Chronic viral infections; HLA; KIR; NK cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / Linfocitos T Límite: Female / Humans / Pregnancy Idioma: En Revista: Immunogenetics Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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