Lysosomal quality control: molecular mechanisms and therapeutic implications.

Yang, Haoxiang; Tan, Jay Xiaojun

Yang, Haoxiang; Tan, Jay Xiaojun.

Afiliación

Yang H; Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA.
Tan JX; Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA 15219, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: jay.tan@pitt.edu.

Trends Cell Biol ; 33(9): 749-764, 2023 09.

Article en En | MEDLINE | ID: mdl-36717330

RESUMEN

Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic enzymes. The detrimental consequences of lysosomal leakage have been well known since lysosomes were discovered during the 1950s. However, detailed knowledge of lysosomal quality control mechanisms has only emerged relatively recently. It is now clear that lysosomal leakage triggers multiple lysosomal quality control pathways that replace, remove, or directly repair damaged lysosomes. Here, we review how lysosomal damage is sensed and resolved in mammalian cells, with a focus on the molecular mechanisms underlying different lysosomal quality control pathways. We also discuss the clinical implications and therapeutic potential of these pathways.

Asunto(s)

Autofagia; Lisosomas; Animales; Lisosomas/metabolismo; Mamíferos; Orgánulos

Palabras clave

ESCRT; PITT; TFEB/TFE3; lysophagy; lysosomal biogenesis; lysosomal repair

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Lisosomas Límite: Animals Idioma: En Revista: Trends Cell Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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