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Polygenic plague resistance in the great gerbil uncovered by population sequencing.
Nilsson, Pernille; Ravinet, Mark; Cui, Yujun; Berg, Paul R; Zhang, Yujiang; Guo, Rong; Luo, Tao; Song, Yajun; Trucchi, Emiliano; Hoff, Siv N K; Lv, Ruichen; Schmid, Boris V; Easterday, W Ryan; Jakobsen, Kjetill S; Stenseth, Nils Chr; Yang, Ruifu; Jentoft, Sissel.
Afiliación
  • Nilsson P; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Ravinet M; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Cui Y; School of Life Sciences, University of Nottingham, NG9 8DQ, UK.
  • Berg PR; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
  • Zhang Y; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Guo R; Centre for Coastal Research, Department of Natural Sciences, University of Agder, 4604 Kristiansand, Norway.
  • Luo T; Xinjiang Center for Disease Control and Prevention, Urumqi 830002, China.
  • Song Y; Xinjiang Center for Disease Control and Prevention, Urumqi 830002, China.
  • Trucchi E; Xinjiang Center for Disease Control and Prevention, Urumqi 830002, China.
  • Hoff SNK; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
  • Lv R; Department of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, 60131 Ancona, Italy.
  • Schmid BV; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Easterday WR; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
  • Jakobsen KS; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Stenseth NC; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Yang R; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  • Jentoft S; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
PNAS Nexus ; 1(5): pgac211, 2022 Nov.
Article en En | MEDLINE | ID: mdl-36712379
Pathogens can elicit high selective pressure on hosts, potentially altering genetic diversity over short evolutionary timescales. Intraspecific variation in immune response is observable as variable survivability from specific infections. The great gerbil (Rhombomys opimus) is a rodent plague host with a heterogenic but highly resistant phenotype. Here, we investigate the genomic basis for plague-resistant phenotypes by exposing wild-caught great gerbils to plague (Yersinia pestis). Whole genome sequencing of 10 survivors and 10 moribund individuals revealed a subset of genomic regions showing elevated differentiation. Gene ontology analysis of candidate genes in these regions demonstrated enrichment of genes directly involved in immune functions, cellular metabolism and the regulation of apoptosis as well as pathways involved in transcription, translation, and gene regulation. Transcriptomic analysis revealed that the early activated great gerbil immune response to plague consisted of classical components of the innate immune system. Our approach combining challenge experiments with transcriptomics and population level sequencing, provides new insight into the genetic background of plague-resistance and confirms its complex nature, most likely involving multiple genes and pathways of both the immune system and regulation of basic cellular functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: PNAS Nexus Año: 2022 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: PNAS Nexus Año: 2022 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido