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Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy.
Dolmaci, Onur B; Ayyildiz, Tugay; Poelmann, Robert E; Driessen, Antoine H G; Koolbergen, Dave R; Klautz, Robert J M; Lindeman, Jan H N; Grewal, Nimrat.
Afiliación
  • Dolmaci OB; Department of Cardiothoracic Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands.
  • Ayyildiz T; Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands.
  • Poelmann RE; Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands.
  • Driessen AHG; Institute of Biology, Animal Sciences and Health, Leiden University, Leiden, Netherlands.
  • Koolbergen DR; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.
  • Klautz RJM; Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands.
  • Lindeman JHN; Department of Cardiothoracic Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands.
  • Grewal N; Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands.
Front Cardiovasc Med ; 9: 1036522, 2022.
Article en En | MEDLINE | ID: mdl-36712236
Objective: Patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions share many pathophysiological mechanisms leading to aortic complications. Bicuspidy is known to have a low risk for acquired coronary artery sclerosis. The aim of this study is to determine the risk of coronary sclerosis in MFS patients. Methods: Marfan syndrome patients with an aortic root dilatation, which were surgically treated between 1999 and 2017, were included and matched with BAV and tricuspid aortic valves (TAV) patients based on sex and age. Cardiovascular risk profiles were determined in all three groups. Coronary sclerosis was graded in all patients on coronary imaging (coronary angiography or computed tomography) using a coronary artery scoring method, which divides the coronaries in 28 segments and scores non-obstructive (20-49% sclerosis) and obstructive coronary sclerosis (>49% sclerosis) in each segment. Results: A total of 90 matched patients (30 within each group) were included. MFS patients showed less cardiovascular risk factors compared to BAV and TAV patients. TAV patients had higher amounts of obstructive coronary sclerosis as compared to BAV patients (p = 0.039) and MFS patients (p = 0.032). No difference in non- and obstructive coronary artery disease (CAD) was found between the MFS and BAV population. Conclusion: Marfan syndrome and bicuspid aortic valve patients have a significantly lower risk for, and prevalence of CAD as compared to TAV individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza