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Past, present and future of Focused Ultrasound as an adjunct or complement to DIPG/DMG therapy: A consensus of the 2021 FUSF DIPG meeting.
Parekh, Kavya; LeBlang, Suzanne; Nazarian, Javad; Mueller, Sabine; Zacharoulis, Stergios; Hynynen, Kullervo; Powlovich, Lauren.
Afiliación
  • Parekh K; University of Virginia, Charlottesville, Virginia, USA; Focused Ultrasound Foundation, Charlottesville, Virginia, USA.
  • LeBlang S; Focused Ultrasound Foundation, Charlottesville, Virginia, USA.
  • Nazarian J; Children's National Hospital, Washington DC, USA.
  • Mueller S; University of California San Francisco, San Francisco, California, USA.
  • Zacharoulis S; Bristol-Meyers-Squibb, New York, New York, USA; Columbia University Medical Center Department of Pediatric Oncology, New York, New York, USA.
  • Hynynen K; Sunnybrook Research Institute, Toronto, Canada.
  • Powlovich L; Focused Ultrasound Foundation, Charlottesville, Virginia, USA. Electronic address: lpowlovich@fusfoundation.org.
Neoplasia ; 37: 100876, 2023 03.
Article en En | MEDLINE | ID: mdl-36709715
Diffuse Intrinsic Pontine Glioma (DIPG), now known as Diffuse Midline Glioma (DMG) is a devastating pediatric brain tumor with limited treatment options and a very poor prognosis. Despite more than 250 clinical trials aimed to treat children diagnosed with DMG, no curative therapies currently exist for this patient population. A major obstacle has been the intact blood brain barrier (BBB) which prevents most therapeutics from crossing into the tumor bed. Focused Ultrasound (FUS) is an emerging, noninvasive medical technology which has been shown in both preclinical and clinical research to disrupt the blood brain barrier safely and temporarily. FUS blood brain barrier opening has been studied in combination with chemotherapies in preclinical DMG models, and this technology is now being investigated in clinical trials for the treatment of pediatric brain tumors. Focused ultrasound has additional mechanisms of action, including sonodynamic therapy and radiation sensitization, that hold promise as future DMG therapies as well. This paper, largely based off the proceedings from a workshop held by the Focused Ultrasound Foundation in October of 2021, summarizes the current state of the field of focused ultrasound for DIPG/DMG, including preclinical, technical, and clinical summaries in addition to recommended next steps for continued advancement of the game changing technology of Focused Ultrasound.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Tronco Encefálico Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Child / Humans Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Tronco Encefálico Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Child / Humans Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos