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No Polarity-specific Modulation of Prefrontal-to-M1 Interhemispheric Inhibition by Transcranial Direct Current Stimulation Over the Lateral Prefrontal Cortex.
Uehara, Shintaro; Mawase, Firas; Cherry-Allen, Kendra M; Runnalls, Keith; Khan, Maheen; Celnik, Pablo.
Afiliación
  • Uehara S; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD, USA; School of Health Sciences, Fujita Health University, Aichi, Japan. Electronic address: suehara@fujita-hu.ac.jp.
  • Mawase F; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD, USA; Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
  • Cherry-Allen KM; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Runnalls K; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Khan M; Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
  • Celnik P; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: pcelnik@jhmi.edu.
Neuroscience ; 513: 54-63, 2023 03 01.
Article en En | MEDLINE | ID: mdl-36708800
The lateral prefrontal cortex (PFC) plays a variety of crucial roles in higher-order cognitive functions. Previous works have attempted to modulate lateral PFC function by applying non-invasive transcranial direct current stimulation (tDCS) and demonstrated positive effects on performance of tasks involving cognitive processes. The neurophysiological underpinning of the stimulation effects, however, remain poorly understood. Here, we explored the neurophysiological after-effects of tDCS over the lateral PFC by assessing changes in the magnitude of interhemispheric inhibition from the lateral PFC to the contralateral primary motor cortex (PFC-M1 IHI). Using a dual-site transcranial magnetic stimulation paradigm, we assessed PFC-M1 IHI before and after the application of tDCS over the right lateral PFC. We conducted a double-blinded, crossover, and counterbalanced design where 15 healthy volunteers participated in three sessions during which they received either anodal, cathodal, and sham tDCS. In order to determine whether PFC-M1 IHI could be modulated at all, we completed the same assessment on a separate group of 15 participants as they performed visuo-motor reaction tasks that likely engage the lateral PFC. The results showed that tDCS over the right lateral PFC did not modulate the magnitude of PFC-M1 IHI, whereas connectivity changed when Go/NoGo decisions were implemented in reactions during the motor tasks. Although PFC-M1 IHI is sensitive enough to be modulated by behavioral manipulations, tDCS over the lateral PFC does not have substantial modulatory effects on PFC to M1 functional connectivity, or at least not to the degree that can be detected with this measure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Transcraneal de Corriente Directa / Corteza Motora Límite: Humans Idioma: En Revista: Neuroscience Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Transcraneal de Corriente Directa / Corteza Motora Límite: Humans Idioma: En Revista: Neuroscience Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos