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Effects of Simulated Gastrointestinal Conditions on Combined Potentially Probiotic Limosilactobacillus fermentum 296, Quercetin, and/or Resveratrol as Bioactive Components of Novel Nutraceuticals.
Sampaio, Karoliny Brito; de Brito Alves, José Luiz; do Nascimento, Yuri Mangueira; Tavares, Josean Fechine; da Silva, Marcelo Sobral; Dos Santos Nascimento, Davi; de Araújo Rodrigues, Noádia Priscila; Monteiro, Mariana Costa; Garcia, Estefânia Fernandes; de Souza, Evandro Leite.
Afiliación
  • Sampaio KB; Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - Cidade Universitária, CEP, João Pessoa, PB, 58051-900, Brazil.
  • de Brito Alves JL; Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - Cidade Universitária, CEP, João Pessoa, PB, 58051-900, Brazil.
  • do Nascimento YM; Institute for Research in Drugs and Medicines, Federal University of Paraíba, João Pessoa, PB, Brazil.
  • Tavares JF; Institute for Research in Drugs and Medicines, Federal University of Paraíba, João Pessoa, PB, Brazil.
  • da Silva MS; Institute for Research in Drugs and Medicines, Federal University of Paraíba, João Pessoa, PB, Brazil.
  • Dos Santos Nascimento D; Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - Cidade Universitária, CEP, João Pessoa, PB, 58051-900, Brazil.
  • de Araújo Rodrigues NP; Department of Gastronomy, Center of Technology and Regional Development, Federal University of Paraíba, João Pessoa, PB, Brazil.
  • Monteiro MC; Laboratory of Functional Foods, Institute of Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Garcia EF; Department of Gastronomy, Center of Technology and Regional Development, Federal University of Paraíba, João Pessoa, PB, Brazil.
  • de Souza EL; Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - Cidade Universitária, CEP, João Pessoa, PB, 58051-900, Brazil. els@academico.ufpb.br.
Probiotics Antimicrob Proteins ; 16(1): 308-319, 2024 Feb.
Article en En | MEDLINE | ID: mdl-36708461
This study evaluated the effects of simulated gastrointestinal conditions (SGIC) on combined potentially probiotic Limosilactobacillus fermentum 296 (~ 10 log CFU/mL), quercetin (QUE, 160 mg), and/or resveratrol (RES, 150 mg) as the bioactive components of novel nutraceuticals. Four different nutraceuticals were evaluated during exposure to SGIC and analyzed the plate counts and physiological status of L. fermentum 296, contents and bioaccessibility of QUE and RES, and antioxidant capacity. Nutraceuticals with QUE and RES had the highest plate counts (4.94 ± 0.32 log CFU/mL) and sizes of live cell subpopulations (28.40 ± 0.28%) of L. fermentum 296 after SGIC exposure. An index of injured cells (Gmean index, arbitrary unit defined as above 0.5) indicated that part of L. fermentum 296 cells could be entered the viable but nonculturable state when the nutraceuticals were exposed to gastric and intestinal conditions while maintaining vitality. The nutraceuticals maintained high contents (QUE ~ 29.17 ± 0.62 and RES ~ 23.05 mg/100 g) and bioaccessibility (QUE ~ 41.0 ± 0.09% and RES ~ 67.4 ± 0.17%) of QUE and RES, as well as high antioxidant capacity (ABTS assay ~ 88.18 ± 1.16% and DPPH assay 75.54 ± 0.65%) during SGIC exposure, which could be linked to the protective effects on L. fermentum 296 cells. The developed nutraceuticals could cross along the gastrointestinal tract with high concentrations of functioning potentially probiotic cells and bioavailable phenolic compounds to exert their beneficial impacts on consumer health, being an innovative strategy for the co-ingestion of these bioactive components.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Limosilactobacillus fermentum / Enfermedades Gastrointestinales Límite: Humans Idioma: En Revista: Probiotics Antimicrob Proteins Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Limosilactobacillus fermentum / Enfermedades Gastrointestinales Límite: Humans Idioma: En Revista: Probiotics Antimicrob Proteins Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos