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Fullerene C60 Attenuates Heart Tissue Inflammation by Modulating COX-2 and TNF-Alpha Signaling Pathways in DMBA Induced Breast Cancer in Rats.
Beyaz, Seda; Aslan, Abdullah; Gok, Ozlem; Agca, Can Ali; Ozercan, Ibrahim Hanifi.
Afiliación
  • Beyaz S; Faculty of Science, Department of Biology-Molecular Biology and Genetics Program, Firat University, Elazig, Turkey.
  • Aslan A; Faculty of Science, Department of Biology-Molecular Biology and Genetics Program, Firat University, Elazig, Turkey. aaslan@firat.edu.tr.
  • Gok O; Faculty of Science, Department of Biology-Molecular Biology and Genetics Program, Firat University, Elazig, Turkey.
  • Agca CA; Faculty of Science, Department of Molecular Biology and Genetics, Bingol University, Bingol, Turkey.
  • Ozercan IH; Medical School, Department of Pathology, Firat University, Elazig, Turkey.
Cardiovasc Toxicol ; 23(2): 75-85, 2023 02.
Article en En | MEDLINE | ID: mdl-36705854
The present study aimed to investigate the therapeutic effect of fullerene C60 nanoparticle against heart tissue damage caused by 7,12-dimethylbenz [a] anthracene (DMBA) in female rats. Female Wistar albino rats, 8 weeks old (n = 60) weighing around (150 ± 10 g) were used for the study. These rats were divided into 4 groups and each group included 15 rats. Groups: (i) Control Group: Fed with standard diet; (ii) C60 Group: C60 (1.7 mg/kg bw, oral gavage); (iii) DMBA Group: DMBA (45 mg/kg bw, oral gavage); (iv) C60 and DMBA Group: C60 (1.7 mg/kg bw, oral gavage) and DMBA (45 mg/kg bw, oral gavage) group. Malondialdehyde (MDA) analysis, catalase activity (CAT), and glutathione (GSH) in heart tissue were determined by spectrophotometer. In addition, heart tissue DNA damage was investigated. Caspase-3, p53, HO-1, COX-2, and TNF-α protein expression levels in heart tissue were determined by western blotting. As a result, Caspase-3, p53, HO-1 protein expression, GSH levels and CAT activity increased, COX-2, TNF-α protein expression, and MDA levels were significantly decreased in the C60 + DMBA group compared to the DMBA group. Therefore, the fullerene C60 nanoparticle may be a promising and effective therapy for the treatment of heart diseases associated with inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fulerenos / Neoplasias Límite: Animals Idioma: En Revista: Cardiovasc Toxicol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fulerenos / Neoplasias Límite: Animals Idioma: En Revista: Cardiovasc Toxicol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos