Brain Data Standards - A method for building data-driven cell-type ontologies.
Sci Data
; 10(1): 50, 2023 01 24.
Article
en En
| MEDLINE
| ID: mdl-36693887
Large-scale single-cell 'omics profiling is being used to define a complete catalogue of brain cell types, something that traditional methods struggle with due to the diversity and complexity of the brain. But this poses a problem: How do we organise such a catalogue - providing a standard way to refer to the cell types discovered, linking their classification and properties to supporting data? Cell ontologies provide a partial solution to these problems, but no existing ontology schemas support the definition of cell types by direct reference to supporting data, classification of cell types using classifications derived directly from data, or links from cell types to marker sets along with confidence scores. Here we describe a generally applicable schema that solves these problems and its application in a semi-automated pipeline to build a data-linked extension to the Cell Ontology representing cell types in the Primary Motor Cortex of humans, mice and marmosets. The methods and resulting ontology are designed to be scalable and applicable to similar whole-brain atlases currently in preparation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Ontologías Biológicas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Sci Data
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Reino Unido