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Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series.
Anderson, Jenna; Frost, Spencer; Keyashian, Kian; Modiano, Nir.
Afiliación
  • Anderson J; Oregon Health & Science University, Department of Medicine, Division of Gastroenterology & Hepatology, Portland, Oregon, USA.
  • Frost S; Stanford University, Department of Medicine, Division of Gastroenterology & Hepatology, Stanford, California, USA.
  • Keyashian K; Stanford University, Department of Medicine, Division of Gastroenterology & Hepatology, Stanford, California, USA.
  • Modiano N; Oregon Health & Science University, Department of Medicine, Division of Gastroenterology & Hepatology, Portland, Oregon, USA.
Am J Gastroenterol ; 118(5): 905-908, 2023 05 01.
Article en En | MEDLINE | ID: mdl-36689730
INTRODUCTION: This study evaluates the potential association of pentosan polysulfate (PPS) with inflammatory bowel disease (IBD) or dysplasia. METHODS: We searched electronic medical records to identify patients with IBD using PPS. RESULTS: Ten of 30 identified patients (33.3%) had colonic dysplasia. Six of them (60%) underwent colectomy for endoscopically unresectable dysplasia. Three (10%) discontinued PPS, each with an apparent benefit. DISCUSSION: Patients with IBD at 2 institutions who had taken PPS had high rates of colonic dysplasia leading to surgery. Patients who stopped PPS showed improvement in their colitis. PPS may play a causal role in the development of colitis and dysplasia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Am J Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Am J Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos