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Dual actions of gallic acid and andrographolide trigger AdipoR1 to stimulate insulin secretion in a streptozotocin-induced diabetes rat model.
Wong, Tet Soon; Mohamed Tap, Fatahiya; Hashim, Zanariah; Abdul Majid, Fadzilah Adibah; Zakaria, Nor Hafizah; Siahaan, Parsaoran; Mogadem, Abeer.
Afiliación
  • Wong TS; School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, Johor, Malaysia.
  • Mohamed Tap F; School of Chemical Engineering, College of Engineering, Universiti Teknologi MARA Bukit Besi, 23200, Dungun, Terengganu, Malaysia.
  • Hashim Z; School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, Johor, Malaysia.
  • Abdul Majid FA; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
  • Zakaria NH; Department of Chemistry, Diponegoro University, Semarang, Indonesia.
  • Siahaan P; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
  • Mogadem A; Department of Chemistry, Diponegoro University, Semarang, Indonesia.
J Tradit Complement Med ; 13(1): 11-19, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36685073
Common treatments for the management of diabetes have limitations due to side effects, hence the need for continuous research to discover new remedies with better therapeutic efficacy. Previously, we have reported that the combination treatment of gallic acid (20 mg/kg) and andrographolide (10 mg/kg) for 15 days demonstrated synergistic hypoglycemic activity in the streptozotocin (STZ)-induced insulin-deficient diabetes rat model. Here, we attempt to further elucidate the effect of this combination therapy at the biochemical, histological and molecular levels. Our biochemical analyses showed that the combination treatment significantly increased the serum insulin level and decreased the total cholesterol and triglyceride level of the diabetic animals. Histological examinations of H&E stained pancreas, liver, kidney and adipose tissues of combination-treated diabetic animals showed restoration to the normalcy of the tissues. Besides, the combination treatment significantly enhanced the level of glucose transporter-4 (GLUT4) protein expression in the skeletal muscle of treated diabetic animals compared to single compound treated and untreated diabetic animals. The molecular docking analysis on the interaction of gallic acid and/or andrographolide with the adiponectin receptor 1 (AdipoR1), a key component in the regulation of pancreatic insulin secretion, revealed a greater binding affinity of AdipoR1 to both compounds compared to individual compounds. Taken together, these findings suggest the combination of gallic acid and andrographolide as a potent therapy for the management of diabetes mellitus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Tradit Complement Med Año: 2023 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Tradit Complement Med Año: 2023 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Países Bajos