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S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Chen, Buran; Zheng, Danni; Liu, Conghui; Bhandari, Adheesh; Hirachan, Suzita; Shen, Cuihua; Mainali, Sumnima; Li, Huihui; Jiang, Wenjie; Xu, Jie; Zhang, Xiaohua; Tang, Kaifu; Zhang, Wei.
Afiliación
  • Chen B; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Zheng D; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Liu C; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Bhandari A; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Hirachan S; Department of General Surgery, Breast and Thyroid Unit, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
  • Shen C; Department of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Mainali S; Department of Obstetrics and Gynecology, Kulhudhuffushi Regional Hospital, Kulhudhuffushi, Maldives.
  • Li H; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Jiang W; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Xu J; Department of ICU, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Zhang X; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
  • Tang K; Key Laboratory of Diagnosis and Treatment of Severe Hepatopancreatic Diseases Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: kaifutang@outlook.com.
  • Zhang W; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: wei_zhang112@outlook.com.
Pathol Res Pract ; 242: 154325, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36680929
High levels of S100A6 have been associated with progression in some types of human cancers. Cancers related to S100A6 have been reported to include lung cancer, cervical cancer, pancreatic cancer, gastric cancer, colon cancer, etc., but its role in the molecular pathogenesis of these cancers is largely unknown. This study investigated the expression and functional roles of S100A6 in human thyroid cancer. The expression level of S100A6 in thyroid cancer cells was determined by bioinformatics and transcriptomic analysis. Furthermore, the potential functions of S100A6 in tumorigenesis were analyzed by cell proliferation, migration, invasion, and Western blot assays in human thyroid cancer cells. Public database queries revealed high S100A6 expression in thyroid cancer. In addition, we also found that high expression of S100A6 was positively correlated with malignant clinicopathological characteristics of thyroid cancer in The Cancer Genome Atlas database. qPCR results confirmed the high expression of S100A6 in thyroid cancer cells. S100A6 silencing inhibited cell proliferation, migration, and invasion. Western blot assays and response experiments showed that S100A6 promotes cell proliferation and tumorigenicity partly through the PI3K/AKT/mTOR signaling pathway. These results suggest that S100A6 affects the progression of thyroid cancer and can be used as a target in the future treatment of thyroid cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Proteína A6 de Unión a Calcio de la Familia S100 Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2023 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Proteína A6 de Unión a Calcio de la Familia S100 Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2023 Tipo del documento: Article Pais de publicación: Alemania