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Molecular Epidemiology of HIV-1 in Ghana: Subtype Distribution, Drug Resistance and Coreceptor Usage.
Appah, Anna; Beelen, Charlotte J; Kirkby, Don; Dong, Winnie; Shahid, Aniqa; Foley, Brian; Mensah, Miriam; Ganu, Vincent; Puplampu, Peter; Amoah, Linda E; Nii-Trebi, Nicholas I; Brumme, Chanson J; Brumme, Zabrina L.
Afiliación
  • Appah A; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
  • Beelen CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.
  • Kirkby D; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.
  • Dong W; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.
  • Shahid A; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.
  • Foley B; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
  • Mensah M; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.
  • Ganu V; Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
  • Puplampu P; Fevers Unit, Department of Medicine, Korle Bu Teaching Hospital, Accra P.O. Box KB 77, Ghana.
  • Amoah LE; Department of Internal Medicine, Korle Bu Teaching Hospital, Accra P.O. Box KB 77, Ghana.
  • Nii-Trebi NI; Department of Internal Medicine, Korle Bu Teaching Hospital, Accra P.O. Box KB 77, Ghana.
  • Brumme CJ; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra P.O. Box LG 581, Ghana.
  • Brumme ZL; Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Accra P.O. Box LG 25, Ghana.
Viruses ; 15(1)2022 12 31.
Article en En | MEDLINE | ID: mdl-36680168
The greatest HIV-1 genetic diversity is found in West/Central Africa due to the pandemic's origins in this region, but this diversity remains understudied. We characterized HIV-1 subtype diversity (from both sub-genomic and full-genome viral sequences), drug resistance and coreceptor usage in 103 predominantly (90%) antiretroviral-naive individuals living with HIV-1 in Ghana. Full-genome HIV-1 subtyping confirmed the circulating recombinant form CRF02_AG as the dominant (53.9%) subtype in the region, with the complex recombinant 06_cpx (4%) present as well. Unique recombinants, most of which were mosaics containing CRF02_AG and/or 06_cpx, made up 37% of sequences, while "pure" subtypes were rare (<6%). Pretreatment resistance to at least one drug class was observed in 17% of the cohort, with NNRTI resistance being the most common (12%) and INSTI resistance being relatively rare (2%). CXCR4-using HIV-1 sequences were identified in 23% of participants. Overall, our findings advance our understanding of HIV-1 molecular epidemiology in Ghana. Extensive HIV-1 genetic diversity in the region appears to be fueling the ongoing creation of novel recombinants, the majority CRF02_AG-containing, in the region. The relatively high prevalence of pretreatment NNRTI resistance but low prevalence of INSTI resistance supports the use of INSTI-based first-line regimens in Ghana.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Seropositividad para VIH Tipo de estudio: Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Seropositividad para VIH Tipo de estudio: Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza