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Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer.
Pérez-Martín, Hipólito; Lidón-Moyano, Cristina; González-Marrón, Adrián; Fu, Marcela; Pérez-Ortuño, Raúl; Ballbè, Montse; Martín-Sánchez, Juan Carlos; Pascual, José A; Fernández, Esteve; Martínez-Sánchez, Jose M.
Afiliación
  • Pérez-Martín H; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Barcelona, Spain.
  • Lidón-Moyano C; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Barcelona, Spain.
  • González-Marrón A; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Barcelona, Spain.
  • Fu M; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, 08908 Barcelona, Spain.
  • Pérez-Ortuño R; Tobacco Control Research Group, Epidemiology and Public Health Program, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
  • Ballbè M; School of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain.
  • Martín-Sánchez JC; Center for Biomedical Research in Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, 28220 Madrid, Spain.
  • Pascual JA; Group of Integrative Pharmacology and Systems Neuroscience, Neurosciences Programme, IMIM (Hospital del Mar Medical Research Institute), Parc de Recerca Biomèdica de Barcelona, 08003 Barcelona, Spain.
  • Fernández E; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, 08908 Barcelona, Spain.
  • Martínez-Sánchez JM; Tobacco Control Research Group, Epidemiology and Public Health Program, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Healthcare (Basel) ; 11(2)2023 Jan 06.
Article en En | MEDLINE | ID: mdl-36673548
This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3'-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18−44 years) have a higher rate of nicotine metabolism than older individuals (45−64 years and 65−89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21−25 kg/m2) have a higher rate of nicotine metabolism than the rest (26−30 kg/m2 and 31−60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: Healthcare (Basel) Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: Healthcare (Basel) Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza