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Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification.
Zhou, Jinwen; Gummi, Manasa Reddy; Greco, Anna; Babic, Milen; Herrmann, Jaqueline; Kandil, Farid I; van der Giet, Markus; Tölle, Markus; Schuchardt, Mirjam.
Afiliación
  • Zhou J; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Gummi MR; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Greco A; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Babic M; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Herrmann J; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Kandil FI; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Social Medicine, Epidemiology and Health Economics, Luisenstraße 57, 10117 Berlin, Germany.
  • van der Giet M; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Oncology/Hematology, Otto-Heubner Centre for Pediatric and Adolescent Medicine, Augustenburger Platz 1, 13353 Berlin, Germany.
  • Tölle M; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Schuchardt M; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Hindenburgdamm 30, 12203 Berlin, Germany.
Biomedicines ; 11(1)2023 Jan 14.
Article en En | MEDLINE | ID: mdl-36672718
Medial vascular calcification (MAC) is characterized by the deposition of hydroxyapatite (HAP) in the medial layer of the vessel wall, leading to disruption of vessel integrity and vascular stiffness. Because currently no direct therapeutic interventions for MAC are available, studying the MAC pathogenesis is of high research interest. Several methods exist to measure and describe the pathophysiological processes in the vessel wall, such as histological staining and gene expression. However, no method describing the physiological properties of the arterial wall is currently available. This study aims to close that gap and validate a method to measure the biomechanical properties of the arterial wall during vascular calcification. Therefore, a stress-stretch curve is monitored using small-vessel-myography upon ex vivo calcification of rat aortic tissue. The measurement of biomechanical properties could help to gain further insights into vessel integrity during calcification progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza