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Wnt/ß-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers.
Muto, Satoshi; Enta, Akio; Maruya, Yoshiyuki; Inomata, Sho; Yamaguchi, Hikaru; Mine, Hayato; Takagi, Hironori; Ozaki, Yuki; Watanabe, Masayuki; Inoue, Takuya; Yamaura, Takumi; Fukuhara, Mitsuro; Okabe, Naoyuki; Matsumura, Yuki; Hasegawa, Takeo; Osugi, Jun; Hoshino, Mika; Higuchi, Mitsunori; Shio, Yutaka; Hamada, Kazuyuki; Suzuki, Hiroyuki.
Afiliación
  • Muto S; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Enta A; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Maruya Y; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Inomata S; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Yamaguchi H; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Mine H; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Takagi H; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Ozaki Y; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Watanabe M; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Inoue T; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Yamaura T; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Fukuhara M; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Okabe N; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Matsumura Y; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Hasegawa T; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Osugi J; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Hoshino M; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Higuchi M; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Shio Y; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Hamada K; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
  • Suzuki H; Department of Chest Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Biomedicines ; 11(1)2023 Jan 12.
Article en En | MEDLINE | ID: mdl-36672698
Lung cancer is the leading cause of cancer-related deaths worldwide. The standard of care for advanced non-small-cell lung cancer (NSCLC) without driver-gene mutations is a combination of an anti-PD-1/PD-L1 antibody and chemotherapy, or an anti-PD-1/PD-L1 antibody and an anti-CTLA-4 antibody with or without chemotherapy. Although there were fewer cases of disease progression in the early stages of combination treatment than with anti-PD-1/PD-L1 antibodies alone, only approximately half of the patients had a long-term response. Therefore, it is necessary to elucidate the mechanisms of resistance to immune checkpoint inhibitors. Recent reports of such mechanisms include reduced cancer-cell immunogenicity, loss of major histocompatibility complex, dysfunctional tumor-intrinsic interferon-γ signaling, and oncogenic signaling leading to immunoediting. Among these, the Wnt/ß-catenin pathway is a notable potential mechanism of immune escape and resistance to immune checkpoint inhibitors. In this review, we will summarize findings on these resistance mechanisms in NSCLC and other cancers, focusing on Wnt/ß-catenin signaling. First, we will review the molecular biology of Wnt/ß-catenin signaling, then discuss how it can induce immunoediting and resistance to immune checkpoint inhibitors. We will also describe other various mechanisms of immune-checkpoint-inhibitor resistance. Finally, we will propose therapeutic approaches to overcome these mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza