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Caffeine Delays Ethanol-Induced Sedation in Drosophila.
Tremblay, Sonia; Zeng, Yanqiqi; Yue, Aixin; Chabot, Kiana; Mynahan, Abigail; Desrochers, Stephanie; Bridges, Sarra; Ahmad, S Tariq.
Afiliación
  • Tremblay S; Department of Biology, Colby College, Waterville, ME 04901, USA.
  • Zeng Y; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80310, USA.
  • Yue A; Department of Biology, Colby College, Waterville, ME 04901, USA.
  • Chabot K; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
  • Mynahan A; Department of Biology, Colby College, Waterville, ME 04901, USA.
  • Desrochers S; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Bridges S; Department of Biology, Colby College, Waterville, ME 04901, USA.
  • Ahmad ST; New York Institute of Technology College of Osteopathic Medicine, Glen Head, NY 11545, USA.
Biology (Basel) ; 12(1)2022 Dec 30.
Article en En | MEDLINE | ID: mdl-36671755
Caffeine and ethanol are among the most widely available and commonly consumed psychoactive substances. Both interact with adenosine receptor-mediated signaling which regulates numerous neurological processes including sleep and waking behaviors. In mammals, caffeine is an adenosine receptor antagonist and thus acts as a stimulant. Conversely, ethanol is a sedative because it promotes GABAergic neurotransmission, inhibits glutamatergic neurotransmission, and increases the amount of adenosine in the brain. Despite seemingly overlapping interactions, not much is known about the effect of caffeine on ethanol-induced sedation in Drosophila. In this study, using Drosophila melanogaster as a model, we show that caffeine supplementation in food delays the onset of ethanol-induced sedation in males and females of different strains. The resistance to sedation reverses upon caffeine withdrawal. Heterozygous adenosine receptor mutant flies are resistant to sedation. These findings suggest that caffeine and adenosine receptors modulate the sedative effects of ethanol in Drosophila.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Biology (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Biology (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza