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Lemon gum: Non-toxic arabinogalactan isolated from Citrus × latifolia with antiproliferative property against human prostate adenocarcinoma cells.
Ribeiro, Fábio de Oliveira Silva; Oliveira, Fátima de Cássia Evangelista de; Pessoa, Claudia; Dias, Jhones do Nascimento; Albuquerque, Patrícia; Sousa, Edymilaís da Silva; Lima, Sidney Gonçalo de; Lima, Laís Ramos Monteiro de; Sombra, Venicios G; Paula, Regina Célia Monteiro de; Alves, Even Herlany Pereira; Vasconcelos, Daniel Fernando Pereira; Fontenele, Darllan Damasceno; Iles, Bruno; Medeiros, Jand Venes Rolim; Araújo, Alyne Rodrigues de; da Silva, Durcilene Alves; Leite, José Roberto de Souza de Almeida.
Afiliación
  • Ribeiro FOS; Center for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia, Brazil; Research Center on Biodiversity and Biotechnology, BIOTEC, Parnaíba Delta Federal University, UFDPar, Parnaíba, PI, Brazil.
  • Oliveira FCE; Department of Physiology and Pharmacology, Federal University of Ceará, UFC, Fortaleza, CE, Brazil.
  • Pessoa C; Department of Physiology and Pharmacology, Federal University of Ceará, UFC, Fortaleza, CE, Brazil.
  • Dias JDN; Department of Cell Biology, Institute of Biological Sciences, IB, University of Brasília, UnB, Darcy Ribeiro University Campus, Asa Norte, Brasília, Federal District, DF, Brazil.
  • Albuquerque P; Department of Cell Biology, Institute of Biological Sciences, IB, University of Brasília, UnB, Darcy Ribeiro University Campus, Asa Norte, Brasília, Federal District, DF, Brazil.
  • Sousa EDS; Laboratory of Organic Geochemistry, Center for Natural Sciences, Federal University of Piauí, Campus Ministro Petrônio Portela, Brazil.
  • Lima SG; Laboratory of Organic Geochemistry, Center for Natural Sciences, Federal University of Piauí, Campus Ministro Petrônio Portela, Brazil.
  • Lima LRM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, UFC, Fortaleza, CE, Brazil.
  • Sombra VG; Department of Organic and Inorganic Chemistry, Federal University of Ceará, UFC, Fortaleza, CE, Brazil.
  • Paula RCM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, UFC, Fortaleza, CE, Brazil.
  • Alves EHP; Laboratory of Histological Analysis and Preparation (LAPHis), Parnaíba Delta Federal University, UFDPar, Parnaiba, PI, Brazil.
  • Vasconcelos DFP; Laboratory of Histological Analysis and Preparation (LAPHis), Parnaíba Delta Federal University, UFDPar, Parnaiba, PI, Brazil.
  • Fontenele DD; Research Center on Biodiversity and Biotechnology, BIOTEC, Parnaíba Delta Federal University, UFDPar, Parnaíba, PI, Brazil.
  • Iles B; Research Center on Biodiversity and Biotechnology, BIOTEC, Parnaíba Delta Federal University, UFDPar, Parnaíba, PI, Brazil.
  • Medeiros JVR; Research Center on Biodiversity and Biotechnology, BIOTEC, Parnaíba Delta Federal University, UFDPar, Parnaíba, PI, Brazil.
  • Araújo AR; Research Center on Biodiversity and Biotechnology, BIOTEC, Parnaíba Delta Federal University, UFDPar, Parnaíba, PI, Brazil.
  • da Silva DA; Research Center on Biodiversity and Biotechnology, BIOTEC, Parnaíba Delta Federal University, UFDPar, Parnaíba, PI, Brazil. Electronic address: durcileneas@gmail.com.
  • Leite JRSA; Center for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia, Brazil.
Int J Biol Macromol ; 232: 123058, 2023 Mar 31.
Article en En | MEDLINE | ID: mdl-36669633
Lemon gum (LG) obtained from Citrus × latifolia in Brazil was isolated and characterized. In addition, gum biocompatibility was evaluated in vitro and in vivo by Galleria mellonella and mice model. The cytotoxicity against tumor cells was also evaluated. The ratio of arabinose:galactose: rhamnose:4-OMe-glucuronic acid was 1:0.65:0.06:0.15. Small traces of protein were detected, emphasizing the isolate purity. Molar mass was 8.08 × 105 g/mol, with three different degradation events. LG showed antiproliferative activity against human prostate adenocarcinoma cancer cells, with percentage superior to 50 %. In vivo toxicity models demonstrated that LG is biocompatible polymer, with little difference in the parameters compared to control group. These results demonstrate advance in the study of LG composition and toxicity, indicating a potential for several biomedical and biotechnological future applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Citrus Límite: Animals / Humans / Male Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Citrus Límite: Animals / Humans / Male Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos