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Fighting secondary triple-negative breast cancer in cerebellum: A powerful aid from a medicinal mushrooms blend.
Luca, Fabrizio De; Roda, Elisa; Ratto, Daniela; Desiderio, Anthea; Venuti, Maria Teresa; Ramieri, Martino; Bottone, Maria Grazia; Savino, Elena; Rossi, Paola.
Afiliación
  • Luca F; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. Electronic address: fabrizio.deluca01@universitadipavia.it.
  • Roda E; Laboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy. Electronic address: elisa.roda@icsmaugeri.it.
  • Ratto D; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. Electronic address: daniela.ratto01@universitadipavia.it.
  • Desiderio A; Department of Earth and Environmental Science, University of Pavia, 27100 Pavia, Italy. Electronic address: anthea.desiderio01@universitadipavia.it.
  • Venuti MT; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. Electronic address: mariateresa.venuti01@universitadipavia.it.
  • Ramieri M; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. Electronic address: martino.ramieri01@universitadipavia.it.
  • Bottone MG; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. Electronic address: mariagrazia.bottone@unipv.it.
  • Savino E; Department of Earth and Environmental Science, University of Pavia, 27100 Pavia, Italy. Electronic address: elena.savino@unipv.it.
  • Rossi P; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. Electronic address: paola.rossi@unipv.it.
Biomed Pharmacother ; 159: 114262, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36657301
Breast cancer (BC) is the second most common cause of brain metastasis onset in patients, with the cerebellum accounting for the 33% of cases. In the current study, using a 4T1 triple-negative mouse BC model, we revealed that an orally administered medicinal mushrooms (MM) blend, rich in ß-glucans, played a direct and specific anti-cancer action on cerebellar metastases, also bettering locomotor performances. The neuroprotective effect of the MM blend plays through (i) a direct and specific inhibition of cerebellar metastatization pattern typical of TNBC (with an induced reduction of about 50% of metastases density) and (ii) the regulation of apoptosis and proliferation-related genes, as suggested by expression changes of specific molecular markers, i.e. PCNA, p53, Bcl2, BAX, CASP9, CASP3, Hsp70 and AIF. Therefore, inhibiting the metastatization process, triggering a significant apoptosis increase, and lessening cell proliferation, this MM supplement, employed as adjuvant treatment in association with conventional therapy, could represent a promising approach, in the field of Integrative Oncology, for patients' management in both prevention and treatment of brain metastases from BC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Agaricales / Neoplasias de la Mama Triple Negativas Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Agaricales / Neoplasias de la Mama Triple Negativas Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article Pais de publicación: Francia